Best treatments for drug overdose
6 products may treat drug overdose, spanning FDA drug classes such as benzodiazepine antagonist, opioid antagonist, pyrimidine analog. The current highest-rated option is flumazenil. Ranked below by our independent recall-safety rating (rated where FDA data exists) — not medical advice; always consult a professional.
Quick answer: Of the 6 drugs we list for drug overdose, 2 are available as lower-cost generics, spanning classes such as benzodiazepine antagonist, opioid antagonist, pyrimidine analog. They’re ranked by each drug’s FDA recall-safety record — not clinical effectiveness for drug overdose — so confirm the right choice with your prescriber.
Top-rated picks for drug overdose: 1. Flumazenil · 2. Vivitrol · 3. Opvee
| # | Drug | Rating | Type | Form | Class | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|---|
| 1 | 72/100 | Prescription | Injectable | Benzodiazepine Antagonist | Generic | $1 | View → | |
| 2 | 70/100 | Prescription | Kit | Opioid Antagonist | Generic | $36 | View → | |
| 3 | Not yet rated | Prescription | Spray/Inhaler | Opioid Antagonist | No data | — | View → | |
| 4 | Not yet rated | Prescription | Powder | Pyrimidine Analog | No data | — | View → | |
| 5 | Not yet rated | Prescription | Powder | Pyrimidine Analog | No data | — | View → | |
| 6 | Not yet rated | Prescription | Injectable | Opioid Antagonist | No data | — | View → |
Narrow by drug class
Explore the class hubs: opioid antagonist · pyrimidine analog
Full ranking · 6 treatments
flumazenil
PrescriptionFDA-sourced
Flumazenil is a benzodiazepine antagonist used to treat Drug Overdose, Drug-Related Side Effects and Adverse Reactions.
Pharmacy pays
From ~$1.03· 2 formsvivitrol
PrescriptionFDA-sourced
Vivitrol (Naltrexone) is an opioid antagonist used to treat Alcoholism, Opioid-Related Disorders, Drug Overdose.
Pharmacy pays
~$36.35 /30
opvee
PrescriptionFDA-sourced
Opvee (Nalmefene Hydrochloride) is an opioid antagonist used to treat Opioid-Related Disorders, Respiration Disorders, Drug Overdose.
Price varies
vistogard
PrescriptionFDA-sourced
Vistogard (Uridine Triacetate) is a pyrimidine analog used to treat Drug Overdose.
Price varies
xuriden
PrescriptionFDA-sourced
Xuriden (Uridine Triacetate) is a pyrimidine analog used to treat Drug Overdose.
Price varies
zurnai (autoinjector)
PrescriptionFDA-sourced
Zurnai (Autoinjector) (Nalmefene Hydrochloride) is an opioid antagonist used to treat Opioid-Related Disorders, Respiration Disorders, Drug Overdose.
Price varies
Frequently asked
- What treats drug overdose?
- Our catalog lists 6 products that may treat drug overdose, based on NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. They're rated where FDA recall-safety data exists; the current top-rated option is flumazenil.
- What is the best-rated treatment for drug overdose?
- By our independent recall-safety rating — not an efficacy measure — flumazenil ranks highest among the products we list for drug overdose. Always consult a professional.
- How are these treatments ranked?
- By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.
- What types of drugs treat drug overdose?
- Treatments for drug overdose span FDA drug classes including benzodiazepine antagonist, opioid antagonist, pyrimidine analog. Compare every option side by side, ranked by independent rating, above.
Treatment associations are derived from NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. This is general reference, not medical advice — always consult a licensed professional.