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PERTOFRANE vs TOFRANIL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. PERTOFRANE and TOFRANIL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

pertofranetofranil

Rating

70/100
70/100

Pharmacy pays

~$8.39 /30
~$2.54 /30

Type

RX
RX

Active ingredient

DESIPRAMINE HYDROCHLORIDE
IMIPRAMINE HYDROCHLORIDE

Manufacturer

Sanofi Aventis US
Novartis

Dosage forms

Capsule
Tablet, Injectable

Drug class

Tricyclic Antidepressant
Tricyclic Antidepressant

Boxed warning

None
None

Treats

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Pain
Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Enuresis

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Frequently asked questions

Which is better-rated, Pertofrane or Tofranil?

Pertofrane and Tofranil are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Pertofrane or Tofranil?

Tofranil costs pharmacies less to acquire — about $2.54 vs $8.39 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Pertofrane and Tofranil?

Pertofrane contains Desipramine Hydrochloride, while Tofranil contains Imipramine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.