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pertofrane

Pharmaranks rates Pertofrane 3.5/5 for recall safety — an independent score from its FDA recall history and its manufacturer's record. Pertofrane (Desipramine Hydrochloride) is a tricyclic antidepressant used to treat Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Pain, Substance-Related Disorders.

Desipramine Hydrochloride · by Sanofi Aventis US

Available as a generic: Desipramine Hydrochloride

70/100Limited · 1 source

Based on 1 source · Recall-safety score from FDA recall history — this product's own recalls and its manufacturer's record. Not an efficacy or quality rating. methodology →

Rated against independent regulatory sources·Last updated October 10, 2026·How we rate
Verified againstopenFDANIH DailyMedRxClass
~$8.32 /30
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Lower-cost optionsSave up to 69%
This medication~$8.32/30
Cheapest in class · imipramine hydrochloride~$2.59/30
See FDA-approved alternatives

Key facts

Active ingredient
Desipramine Hydrochloride
Form
Capsule
Strength
Desipramine Hydrochloride 25MG · Desipramine Hydrochloride 50MG
Type
Prescription (Rx)
Brand or generic
Brand-name
Manufacturer
Sanofi Aventis US
What the pharmacy pays
~$8.32 for 30 — not your price
FDA application
NDA013621
Availability
Discontinued (per FDA)

Drug class

May treat (source: NIH RxClass)

See how Pertofrane ranks — best-rated tricyclic antidepressant for:

Dosage forms

Capsule

The forms currently marketed in the U.S., per the FDA National Drug Code Directory.

Ways to save

Ask for the generic

Same active ingredient, far cheaper. Is there a generic? →

Request a 90-day supply

Bulk fills usually lower the per-dose price vs monthly refills.

Use copay cards

Manufacturer copay cards & patient-assistance programs — especially for brand drugs.

Compare alternatives

A same-class option may cost less. See alternatives →

Frequently asked questions

What does Pertofrane treat?
Pertofrane (Desipramine Hydrochloride) may be used to treat attention deficit disorder with hyperactivity, depressive disorder, pain, substance-related disorders, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
How is Pertofrane rated?
pharmaranks gives Pertofrane a composite score of 3.5 out of 5, currently based on 1 weighted source (FDA regulatory recall-safety data weighted highest). See our methodology at /how-we-rate.
How much does Pertofrane cost?
Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $8.32 for 30, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins. Pharmacies pay less for a same-class option, Imipramine Hydrochloride — about $2.59 on the same basis.
Is there a coupon or discount for Pertofrane?
pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Pertofrane. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
Who makes Pertofrane?
Pertofrane is marketed by Sanofi Aventis US. You can see Sanofi Aventis US's full profile, rating, and other products on pharmaranks.
Is Pertofrane a brand-name or generic drug?
Pertofrane is a brand-name product with the active ingredient Desipramine Hydrochloride. Lower-cost generic equivalents containing Desipramine Hydrochloride are available — ask your pharmacist.
Is Pertofrane available over the counter?
No. Pertofrane is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
What forms does Pertofrane come in?
Pertofrane is currently marketed as capsule, per the FDA's National Drug Code Directory.
What class of drug is Pertofrane?
Pertofrane is classified as tricyclic antidepressant, per the FDA's Established Pharmacologic Class.
Is Pertofrane FDA-registered?
Pertofrane is on record with the U.S. FDA under application number NDA013621. You can verify this on its official FDA label.
Has Pertofrane been recalled by the FDA?
Pertofrane has no FDA recalls recorded under its own application in the openFDA enforcement database. Its recall-safety score reflects its manufacturer's overall recall record. This is general reference, not medical advice — check the FDA recall database for the latest alerts.
Is Pertofrane safe?
There's no single safe-or-not verdict. pharmaranks gives Pertofrane a recall-safety score of 70/100, based on its FDA recall history (no recalls under its own FDA application) — not an efficacy or side-effect rating. Review its FDA-label side effects and warnings before use, and always consult a licensed professional.

Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.

What people report to the FDA about DESIPRAMINE HYDROCHLORIDE

The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 193 reports naming DESIPRAMINE HYDROCHLORIDE — the active ingredient in Pertofrane, and the FDA flagged 70% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:

  • fatigue14 reports
  • headache13 reports
  • nausea12 reports
  • confusional state11 reports
  • dyspnoea11 reports
  • depression10 reports
  • drug hypersensitivity10 reports
  • hypertension10 reports

Read these as a signal, not a rate. A report does not mean DESIPRAMINE HYDROCHLORIDE caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label.

Source: openFDA drug/event (FAERS), retrieved September 25, 2026.

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