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LANSOPRAZOLE vs PRILOSEC OTC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Rating

New
70/100

Pharmacy pays

~$5.10 /30

Type

RX
OTC

Active ingredient

LANSOPRAZOLE
OMEPRAZOLE MAGNESIUM

Dosage forms

Tablet, orally disintegrating
Tablet, delayed release

Drug class

Proton Pump Inhibitor
Proton Pump Inhibitor

Boxed warning

None
None

Half-life

about 1.5 hours (mean, ±1.0) in healthy adults — the label states the plasma elimination half-life is less than two hours
about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults

Treats

Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux
Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

Get prilosec otchigher-rated option

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Licensed online providers — consult & get prescribed if eligible.

Where to buy

Buy over-the-counter from trusted retailers.

Frequently asked questions

What is the difference between Lansoprazole and Prilosec OTC?

Lansoprazole contains Lansoprazole, while Prilosec OTC contains Omeprazole Magnesium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.