INDOCIN vs LODINE XL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 5, 2026·How we rate

Possible drug interaction. INDOCIN and LODINE XL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	INDOCIN	LODINE XL
Rating	70/100	New
Pharmacy pays	~$4.06 /30	~$18.48 /30
Type	RX	RX
Active ingredient	INDOMETHACIN	ETODOLAC
Manufacturer	Zyla Life Sciences	Wyeth Pharms Inc
Dosage forms	Suppository	Tablet, extended release
Drug class	Nonsteroidal Anti-Inflammatory Drug	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	None	None
Half-life	about 4.5 hours	about 6.4 hours (roughly 6 to 8 hours; label reports a mean terminal half-life of 6.4 hours with 22% coefficient of variation)
Treats	Rheumatoid Arthritis, Bursitis, Patent Ductus Arteriosus	Rheumatoid Arthritis, Osteoarthritis, Pain

indocin lodine xl

Rating

70/100

New

Pharmacy pays

~$4.06 /30

~$18.48 /30

Type

Active ingredient

INDOMETHACIN

ETODOLAC

Manufacturer

Zyla Life Sciences

Wyeth Pharms Inc

Dosage forms

Suppository

Tablet, extended release

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None

Half-life

about 4.5 hours

about 6.4 hours (roughly 6 to 8 hours; label reports a mean terminal half-life of 6.4 hours with 22% coefficient of variation)

Treats

Rheumatoid Arthritis, Bursitis, Patent Ductus Arteriosus

Rheumatoid Arthritis, Osteoarthritis, Pain

Frequently asked questions

Which is cheaper, Indocin or Lodine XL?

Indocin costs pharmacies less to acquire — about $4.06 vs $18.48 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Indocin and Lodine XL?

Indocin contains Indomethacin, while Lodine XL contains Etodolac — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.