ENTEREG vs EVZIO (AUTOINJECTOR)

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. ENTEREG and EVZIO (AUTOINJECTOR) are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ENTEREG	EVZIO (AUTOINJECTOR)
Rating	72/100	New
Pharmacy pays	—	$4.41 /mL
Type	RX	RX
Active ingredient	ALVIMOPAN	NALOXONE HYDROCHLORIDE
Manufacturer	Cubist Pharms LLC	Kaleo Inc
Dosage forms	Capsule	Solution
Drug class	Opioid Antagonist	Opioid Antagonist
Boxed warning	None	None
Half-life	—	30 to 81 minutes (mean 64 ± 12 minutes)
Treats	—	Opioid-Related Disorders, Respiration Disorders, Septic Shock

entereg evzio (autoinjector)

Rating

72/100

New

Pharmacy pays

—

$4.41 /mL

Type

Active ingredient

ALVIMOPAN

NALOXONE HYDROCHLORIDE

Manufacturer

Cubist Pharms LLC

Kaleo Inc

Dosage forms

Capsule

Solution

Drug class

Opioid Antagonist

Boxed warning

None

Half-life

—

30 to 81 minutes (mean 64 ± 12 minutes)

Treats

—

Opioid-Related Disorders, Respiration Disorders, Septic Shock

Frequently asked questions

What is the difference between Entereg and Evzio (Autoinjector)?

Entereg contains Alvimopan, while Evzio (Autoinjector) contains Naloxone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.