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DESYREL vs LEXAPRO

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. DESYREL and LEXAPRO are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
72/100

Pharmacy pays

~$1.52 /30
$0.16 /mL

Type

RX
RX

Active ingredient

TRAZODONE HYDROCHLORIDE
ESCITALOPRAM OXALATE

Manufacturer

Dosage forms

Tablet
Tablet

Drug class

Serotonin Reuptake Inhibitor
Serotonin Reuptake Inhibitor

Boxed warning

None
None

Half-life

about 7 hours (roughly 5 to 9 hours for the slower elimination phase)
about 27 to 32 hours

Treats

Depressive Disorder, Sleep Initiation and Maintenance Disorders
Major Depressive Disorder

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Frequently asked questions

What is the difference between Desyrel and Lexapro?

Desyrel contains Trazodone Hydrochloride, while Lexapro contains Escitalopram Oxalate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.