BENADRYL PRESERVATIVE FREE vs DIPHENHYDRAMINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Attribute	BENADRYL PRESERVATIVE FREE	DIPHENHYDRAMINE HYDROCHLORIDE
Rating	New	New
Pharmacy pays	$0.04 /mL	$0.04 /mL
Type	RX	RX
Active ingredient	DIPHENHYDRAMINE HYDROCHLORIDE	DIPHENHYDRAMINE HYDROCHLORIDE
Manufacturer	Mcneil Cons	Alra
Dosage forms	Injectable	Injectable, Solution, Capsule, Tablet
Drug class	Histamine-1 Receptor Antagonist	Histamine-1 Receptor Antagonist
Boxed warning	None	None
Treats	Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness	Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness

benadryl preservative free diphenhydramine hydrochloride

Rating

New

Pharmacy pays

$0.04 /mL

Type

Active ingredient

DIPHENHYDRAMINE HYDROCHLORIDE

Manufacturer

Mcneil Cons

Alra

Dosage forms

Injectable

Injectable, Solution, Capsule, Tablet

Drug class

Histamine-1 Receptor Antagonist

Boxed warning

None

Treats

Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness

Frequently asked questions

Which is cheaper, Benadryl Preservative Free or Diphenhydramine Hydrochloride?

Pharmacies pay about the same to acquire either one — roughly $0.04 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Benadryl Preservative Free and Diphenhydramine Hydrochloride?

Both Benadryl Preservative Free and Diphenhydramine Hydrochloride share the active ingredient Diphenhydramine Hydrochloride.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.