BENADRYL PRESERVATIVE FREE vs CHLOR-TRIMETON

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. BENADRYL PRESERVATIVE FREE and CHLOR-TRIMETON are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	BENADRYL PRESERVATIVE FREE	CHLOR-TRIMETON
Rating	New	New
Pharmacy pays	$0.04 /mL	—
Type	RX	RX
Active ingredient	DIPHENHYDRAMINE HYDROCHLORIDE	CHLORPHENIRAMINE MALEATE
Manufacturer	Mcneil Cons	Schering
Dosage forms	Injectable	Tablet, extended release, Injectable
Drug class	Histamine-1 Receptor Antagonist	Histamine-1 Receptor Antagonist
Boxed warning	None	None
Treats	Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness	Perennial Allergic Rhinitis, Urticaria

benadryl preservative free chlor-trimeton

Rating

New

Pharmacy pays

$0.04 /mL

—

Type

Active ingredient

DIPHENHYDRAMINE HYDROCHLORIDE

CHLORPHENIRAMINE MALEATE

Manufacturer

Mcneil Cons

Schering

Dosage forms

Injectable

Tablet, extended release, Injectable

Drug class

Histamine-1 Receptor Antagonist

Boxed warning

None

Treats

Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness

Perennial Allergic Rhinitis, Urticaria

Frequently asked questions

What is the difference between Benadryl Preservative Free and Chlor-Trimeton?

Benadryl Preservative Free contains Diphenhydramine Hydrochloride, while Chlor-Trimeton contains Chlorpheniramine Maleate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.