ADZENYS XR-ODT vs QUILLICHEW ER

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. ADZENYS XR-ODT and QUILLICHEW ER are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ADZENYS XR-ODT	QUILLICHEW ER
Rating	New	New
Pharmacy pays	~$478.55 /30	~$18.94 /30
Type	RX	RX
Active ingredient	AMPHETAMINE	METHYLPHENIDATE HYDROCHLORIDE
Manufacturer	Neos Theraps Inc	Nextwave
Dosage forms	Tablet, orally disintegrating	Tablet, chewable, extended release
Drug class	Central Nervous System Stimulant	Central Nervous System Stimulant
Boxed warning	Boxed warning	Boxed warning
Half-life	about 10 to 11 hours for d-amphetamine (range 9.8 to 11 hours) and about 12 to 14 hours for l-amphetamine (range 11.5 to 13.8 hours) in healthy adults	about 2.7 hours
Treats	Attention Deficit Disorder with Hyperactivity, Narcolepsy	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

adzenys xr-odt quillichew er

Rating

New

Pharmacy pays

~$478.55 /30

~$18.94 /30

Type

Active ingredient

AMPHETAMINE

METHYLPHENIDATE HYDROCHLORIDE

Manufacturer

Neos Theraps Inc

Nextwave

Dosage forms

Tablet, orally disintegrating

Tablet, chewable, extended release

Drug class

Central Nervous System Stimulant

Boxed warning

Half-life

about 10 to 11 hours for d-amphetamine (range 9.8 to 11 hours) and about 12 to 14 hours for l-amphetamine (range 11.5 to 13.8 hours) in healthy adults

about 2.7 hours

Treats

Attention Deficit Disorder with Hyperactivity, Narcolepsy

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

Frequently asked questions

Which is cheaper, Adzenys XR-ODT or Quillichew ER?

Quillichew ER costs pharmacies less to acquire — about $18.94 vs $478.55 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Adzenys XR-ODT and Quillichew ER?

Adzenys XR-ODT contains Amphetamine, while Quillichew ER contains Methylphenidate Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.