Best Endothelin Receptor Antagonist for hypertension, pulmonary
Top-rated pick: Letairis — pharmaranks score 70/100, the highest of the 6 Endothelin Receptor Antagonist drugs used for hypertension, pulmonary, ranked by our independent FDA recall-safety score. Compare them with all treatments for hypertension, pulmonary or the full Endothelin Receptor Antagonist class. Not medical advice — always consult a professional.
Quick answer: Of the 6 endothelin receptor antagonist drugs we rate for hypertension, pulmonary, 2 are available as lower-cost generics, and most are tablet. Our ranking reflects each drug’s FDA recall-safety record — not clinical effectiveness for hypertension, pulmonary; the right choice depends on your situation, so confirm it with your prescriber.
How endothelin receptor antagonist work
Endothelin receptor antagonists block endothelin-1, a natural substance that powerfully tightens blood vessels. By stopping it from acting on its receptors, these drugs let vessels relax and widen, lowering pressure in the lung arteries in conditions like pulmonary arterial hypertension.
Other drug classes for hypertension, pulmonary
Top endothelin receptor antagonist for hypertension, pulmonary: 1. Letairis · 2. Ambrisentan · 3. Bosentan
| # | Drug | Rating | Type | Form | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|
| 1 | 70/100 | Prescription | Tablet | Generic | $256 | View → | |
| 2 | 66/100 | Prescription | Tablet | Generic | $256 | View → | |
| 3 | 66/100 | Prescription | Tablet | No data | — | View → | |
| 4 | 66/100 | Prescription | Tablet | No data | — | View → | |
| 5 | Not yet rated | Prescription | Tablet | No data | — | View → | |
| 6 | Not yet rated | Prescription | Tablet | No data | — | View → |
Full ranking · 6 drugs
letairis
Boxed warningPrescriptionFDA-sourced
Letairis (Ambrisentan) is an endothelin receptor antagonist used to treat Pulmonary Hypertension.
Pharmacy pays
~$255.61 /30
ambrisentan
Boxed warningPrescriptionFDA-sourced
Ambrisentan is an endothelin receptor antagonist used to treat Pulmonary Hypertension.
Pharmacy pays
~$255.61 /30
bosentan
Boxed warningPrescriptionFDA-sourced
Bosentan is an endothelin receptor antagonist used to treat Pulmonary Hypertension.
Price varies
macitentan
Boxed warningPrescriptionFDA-sourced
Macitentan is an endothelin receptor antagonist used to treat Pulmonary Hypertension.
Price varies
opsumit
Boxed warningPrescriptionFDA-sourced
Opsumit (Macitentan) is an endothelin receptor antagonist used to treat Pulmonary Hypertension.
Price varies
tracleer
Boxed warningPrescriptionFDA-sourced
Tracleer (Bosentan) is an endothelin receptor antagonist used to treat Pulmonary Hypertension.
Price varies
Frequently asked
- What is the best endothelin receptor antagonist for hypertension, pulmonary?
- By our independent recall-safety rating — not an efficacy measure — letairis ranks highest among Endothelin Receptor Antagonist drugs used for hypertension, pulmonary. Always consult a professional.
- Which endothelin receptor antagonist drugs treat hypertension, pulmonary?
- pharmaranks lists 6 Endothelin Receptor Antagonist products used for hypertension, pulmonary, per NIH RxClass drug-classification data — each independently rated and ranked above.
- How are these ranked?
- By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.