Endothelin Receptor Antagonist drugs compared

Compare all 6 Endothelin Receptor Antagonist drugs side by side, used for conditions such as hypertension, pulmonary. They share one FDA-defined mechanism but differ in approved uses, prescription status, brand-vs-generic options, price, and FDA recall-safety record — which our independent rating scores. The highest-rated is letairis.

Top-rated endothelin receptor antagonist: 1. Letairis · 2. Ambrisentan · 3. Bosentan

Endothelin Receptor Antagonist drugs compared side by side, with pharmaranks' FDA recall-safety rating
Drug	Generic	Form	Status	Used for	Safety ratingFDA recall-based	Pharmacy pays
Letairis	Ambrisentan	Tablet	Prescription	Hypertension, Pulmonary	70/100	$256
Ambrisentan	—	Tablet	Prescription	Hypertension, Pulmonary	66/100	$256
Bosentan	—	Tablet	Prescription	Hypertension, Pulmonary	66/100	—
Macitentan	—	Tablet	Prescription	Hypertension, Pulmonary	66/100	—
Opsumit	Macitentan	Tablet	Prescription	Hypertension, Pulmonary	Not yet rated	—
Tracleer	Bosentan	Tablet	Prescription	Hypertension, Pulmonary	Not yet rated	—

The safety rating column is unique to pharmaranks — an independent 0–100 score from FDA regulatory recall data. Higher is safer. Not medical advice.

Best endothelin receptor antagonist by condition

for pulmonary hypertension

Full ranking · 6 drugs

Frequently asked questions

What is the Endothelin Receptor Antagonist drug class?

Endothelin Receptor Antagonist is an FDA Established Pharmacologic Class (EPC) — a group of drugs that share a mechanism of action. pharmaranks lists 6 Endothelin Receptor Antagonist products, each independently rated.

Are all Endothelin Receptor Antagonist drugs the same?

No. Endothelin Receptor Antagonist drugs share the same core mechanism — that is why they sit in one FDA class — but they differ in their approved uses, available forms, whether they are prescription or over-the-counter, brand-vs-generic options and price, and their FDA recall-safety record.

What conditions do Endothelin Receptor Antagonist drugs treat?

Per NIH RxClass drug-classification data, Endothelin Receptor Antagonist drugs are used for conditions including hypertension, pulmonary.

Which Endothelin Receptor Antagonist drug is best-rated?

By our independent rating, letairis currently ranks highest among Endothelin Receptor Antagonist drugs. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.

Sources: the Endothelin Receptor Antagonist class definition and its member drugs come from the U.S. NLM RxClass (Established Pharmacologic Class); how the class works is summarized from Bosentan - StatPearls - NCBI Bookshelf. Ratings are pharmaranks’ independent FDA recall-safety analysis.