What is the best supplement for heart health?

There's rarely a single best — the options below are the supplements most commonly used for heart health. Evidence strength varies by ingredient and by person. Favor a form from a brand with independent third-party testing (NSF, USP Verified, Informed Sport), and check with a healthcare professional before starting.

Are heart health supplements FDA-approved?

No. The FDA regulates supplements as food, not drugs — they aren't approved for safety and effectiveness before sale. That makes third-party testing and certification the most useful quality signal, which is what we point to.

Do supplements replace medication for heart health?

No. Supplements are not a substitute for prescribed treatment. This page is general reference, not medical advice — talk to a licensed professional, especially if you take medication.

Best supplements for heart health

The 11 supplements people most often use for heart health. Supplements aren't FDA recall-rated like drugs and the evidence varies, so we list them as options — not a fabricated ranking — and tell you what to look for. Not medical advice.

By the pharmaranks editorial teamReviewed against NIH & NCCIH sourcesHow we research

1
CoQ10
Coenzyme Q10
Antioxidant supporting cellular energy and heart health, popular with statin users.
Benefits, dosage & safety →
2
Flaxseed Oil
Flaxseed Oil
A plant source of omega-3 (ALA) for heart and skin.
Benefits, dosage & safety →
3
Garlic Supplement
Allicin
Concentrated garlic (allicin) taken for heart and immune support.
Benefits, dosage & safety →
4
Green Tea Extract
EGCG
A concentrated source of green-tea catechins (EGCG) for antioxidant support.
Benefits, dosage & safety →
5
Krill Oil
Krill Oil
An omega-3 source from krill, with naturally-occurring astaxanthin.
Benefits, dosage & safety →
6
Nattokinase
Nattokinase
An enzyme from fermented soy studied for circulation and cardiovascular support.
Benefits, dosage & safety →
7
Olive Leaf Extract
Oleuropein
An extract rich in oleuropein, taken for immune and cardiovascular support.
Benefits, dosage & safety →
8
Red Yeast Rice
Monacolin K
A fermented rice studied for cholesterol support; contains a naturally-occurring statin-like compound.
Benefits, dosage & safety →
9
Taurine
Taurine
Benefits, dosage & safety →
10
Vitamin D3 + K2
Cholecalciferol & Menaquinone
Combination directing calcium to bones; a top-selling stack.
Benefits, dosage & safety →
11
Vitamin K2
Menaquinone
Vitamin K2 directs calcium to bones and supports cardiovascular health.
Benefits, dosage & safety →

What to look for in a heart health supplement

With supplements, quality varies more by brand than by ingredient. Favor brands with independent third-party testing and certification — NSF, NSF Certified for Sport, USP Verified, Informed Sport — over unverified labels.

Thorne Pure Encapsulations NOW Foods Nordic Naturals Life Extension Garden of Life All tested brands →

FAQ

What is the best supplement for heart health?: There's rarely a single best — the options below are the supplements most commonly used for heart health. Evidence strength varies by ingredient and by person. Favor a form from a brand with independent third-party testing (NSF, USP Verified, Informed Sport), and check with a healthcare professional before starting.
Are heart health supplements FDA-approved?: No. The FDA regulates supplements as food, not drugs — they aren't approved for safety and effectiveness before sale. That makes third-party testing and certification the most useful quality signal, which is what we point to.
Do supplements replace medication for heart health?: No. Supplements are not a substitute for prescribed treatment. This page is general reference, not medical advice — talk to a licensed professional, especially if you take medication.

This page is general reference and not medical advice. Supplement evidence varies and is often limited; statements here have not been evaluated by the FDA. Consult a licensed healthcare professional before starting any supplement.