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zegerid

Zegerid is a combination medicine containing Omeprazole and Sodium Bicarbonate.

Omeprazole and Sodium Bicarbonate · by Santarus

Available as a generic: Omeprazole and Sodium Bicarbonate

Not yet rated· sourced from the FDA label
Rated against independent regulatory sources·Last updated June 7, 2026·How we rate
Verified againstopenFDANIH DailyMedRxClass

Key facts

Active ingredient
Omeprazole and Sodium Bicarbonate
Form
Capsule, Powder
Strength
Omeprazole 40MG/PACKET; Sodium Bicarbonate 1.68GM/PACKET
Type
Prescription (Rx)
Brand or generic
Brand-name
Manufacturer
Santarus
Half-life
about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults (how long it stays in your system)
What the pharmacy pays
~$1.52 for 30 — not your price
FDA application
NDA021706
Availability
Discontinued (per FDA)

How long does Omeprazole and Sodium Bicarbonate stay in your body?

The elimination half-life of omeprazole and sodium bicarbonate is about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. The half-life is longer in older adults (about 1 hour) and in people with chronic liver disease (nearly 3 hours); its metabolites have little or no activity, but because omeprazole irreversibly binds the stomach's acid pump, its acid-blocking effect lasts far longer than this short half-life would suggest.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: OMEPRAZOLE capsule, delayed release — DailyMed (FDA label), Clinical Pharmacology / Pharmacokinetics.

Dosage forms

Capsule and Powder

The forms currently marketed in the U.S., per the FDA National Drug Code Directory.

Ways to save

Ask for the generic

Same active ingredient, far cheaper. Is there a generic? →

Request a 90-day supply

Bulk fills usually lower the per-dose price vs monthly refills.

Use copay cards

Manufacturer copay cards & patient-assistance programs — especially for brand drugs.

Compare alternatives

A same-class option may cost less. See alternatives →

Frequently asked questions

How much does Zegerid cost?
Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $1.52 for 30, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
Is there a coupon or discount for Zegerid?
pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Zegerid. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
Who makes Zegerid?
Zegerid is marketed by Santarus. You can see Santarus's full profile, rating, and other products on pharmaranks.
Is Zegerid a brand-name or generic drug?
Zegerid is a brand-name product with the active ingredient Omeprazole and Sodium Bicarbonate. Lower-cost generic equivalents containing Omeprazole and Sodium Bicarbonate are available — ask your pharmacist.
Is Zegerid available over the counter?
No. Zegerid is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
What forms does Zegerid come in?
Zegerid is currently marketed as capsule and powder, per the FDA's National Drug Code Directory.
Is Zegerid FDA-registered?
Zegerid is on record with the U.S. FDA under application number NDA021706. You can verify this on its official FDA label.

Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.

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