trimethoprim

How long does Trimethoprim stay in your body?

The elimination half-life of trimethoprim is about 8 to 10 hours — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. This is the elimination half-life in adults with normal kidney function, so trimethoprim is largely cleared in roughly 2 days (about 5 half-lives). Trimethoprim is not a prodrug and has no active metabolite that outlasts it — only 10-20% is metabolized (mostly in the liver to inactive oxide and hydroxy derivatives), and the free (unchanged) drug is the therapeutically active form, with the rest excreted unchanged in urine. Because clearance is mainly renal, the half-life lengthens in people with severely impaired kidney function, which calls for dose adjustment or avoiding the drug. Half-life is a clearance measure, not a drug-test detection window.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: TRIMETHOPRIM tablet — DailyMed (Clinical Pharmacology).

Frequently asked questions

What does Trimethoprim treat?

Trimethoprim (Trimethoprim) may be used to treat bronchitis, escherichia coli infections, klebsiella infections, pneumocystis pneumonia, proteus infections, staphylococcal infections, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.

How is Trimethoprim rated?

pharmaranks gives Trimethoprim a composite score of 2.8 out of 5, currently based on 1 weighted source (FDA regulatory recall-safety data weighted highest). See our methodology at /how-we-rate.

How much does Trimethoprim cost?

Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $35.33 for 30, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.

Is there a coupon or discount for Trimethoprim?

pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Trimethoprim. To pay less, Trimethoprim is already a generic — usually the lowest-cost version — so the main levers are comparing cash prices between pharmacies and using a pharmacy discount-card service. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.

Who makes Trimethoprim?

Trimethoprim is marketed by Teva. You can see Teva's full profile, rating, and other products on pharmaranks.

Is Trimethoprim a brand-name or generic drug?

Trimethoprim is a generic medication; its active ingredient is Trimethoprim. Generics contain the same active ingredient as the brand-name original and are usually lower cost.

Is Trimethoprim available over the counter?

No. Trimethoprim is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.

What forms does Trimethoprim come in?

Trimethoprim is currently marketed as tablet, per the FDA's National Drug Code Directory.

What class of drug is Trimethoprim?

Trimethoprim is classified as dihydrofolate reductase inhibitor antibacterial, per the FDA's Established Pharmacologic Class.

Is Trimethoprim FDA-registered?

Trimethoprim is on record with the U.S. FDA under application number ANDA071259. You can verify this on its official FDA label.

Has Trimethoprim been recalled by the FDA?

Trimethoprim has no FDA recalls recorded under its own application in the openFDA enforcement database. Its recall-safety score reflects its manufacturer's overall recall record. This is general reference, not medical advice — check the FDA recall database for the latest alerts.

Is Trimethoprim safe?

There's no single safe-or-not verdict. pharmaranks gives Trimethoprim a recall-safety score of 56/100, based on its FDA recall history (no recalls under its own FDA application) — not an efficacy or side-effect rating. Review its FDA-label side effects and warnings before use, and always consult a licensed professional.