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subsys

Subsys (Fentanyl) is an opioid agonist used to treat Pain.

Fentanyl · by Btcp Pharma

Available as a generic: Fentanyl-100

⚠ FDA reports a current shortage of the injection form — availability differs between suppliers — see drug shortages →
Not yet rated· sourced from the FDA label
Rated against independent regulatory sources·Last updated June 7, 2026·How we rate
Verified againstopenFDANIH DailyMedRxClass
Lower-cost optionsSave up to 99%
This medication~$9.51
Cheapest in class · imodium a-d~$0.05
See FDA-approved alternatives

Key facts

Active ingredient
Fentanyl
Drug class
Opioid Agonist
Form
Spray/Inhaler
Strength
Fentanyl 0.1MG **Federal Register Determination That Product was not Discontinued or Withdrawn for Safety or Effectiveness reasons** · Fentanyl 0.2MG **Federal Register Determination That Product was not Discontinued or Withdrawn for Safety or Effectiveness reasons** · Fentanyl 0.4MG **Federal Register Determination That Product was not Discontinued or Withdrawn for Safety or Effectiveness reasons** · Fentanyl 0.6MG **Federal Register Determination That Product was not Discontinued or Withdrawn for Safety or Effectiveness reasons** · Fentanyl 0.8MG **Federal Register Determination That Product was not Discontinued or Withdrawn for Safety or Effectiveness reasons** · Fentanyl 1.2MG **Federal Register Determination That Product was not Discontinued or Withdrawn for Safety or Effectiveness reasons** · Fentanyl 1.6MG **Federal Register Determination That Product was not Discontinued or Withdrawn for Safety or Effectiveness reasons**
Type
Prescription (Rx)
Brand or generic
Brand-name
May treat
pain
Manufacturer
Btcp Pharma
What the pharmacy pays
~$9.51 per ml — not your price
FDA application
NDA202788
Availability
Discontinued (per FDA)

Drug class

How this class works, per Mu Receptors - StatPearls - NCBI Bookshelf.

May treat (source: NIH RxClass)

See how Subsys ranks — best-rated opioid agonist for:

Dosage forms

Spray/Inhaler

The forms currently marketed in the U.S., per the FDA National Drug Code Directory.

Ways to save

Ask for the generic

Same active ingredient, far cheaper. Is there a generic? →

Request a 90-day supply

Bulk fills usually lower the per-dose price vs monthly refills.

Use copay cards

Manufacturer copay cards & patient-assistance programs — especially for brand drugs.

Compare alternatives

A same-class option may cost less. See alternatives →

Frequently asked questions

What does Subsys treat?
Subsys (Fentanyl) may be used to treat pain, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
How does Subsys work?
Subsys is a opioid agonist. Opioid agonists bind opioid receptors (mainly mu receptors) on nerves in the brain and spinal cord, dampening the release of pain-signaling chemicals so fewer pain messages reach the brain, which relieves moderate to severe pain.
How much does Subsys cost?
Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $9.51 per ml, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins. Pharmacies pay less for a same-class option, Imodium A-D — about $0.05 on the same basis.
Is there a coupon or discount for Subsys?
pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Subsys. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
Who makes Subsys?
Subsys is marketed by Btcp Pharma. You can see Btcp Pharma's full profile, rating, and other products on pharmaranks.
Is Subsys a brand-name or generic drug?
Subsys is a brand-name product with the active ingredient Fentanyl. Lower-cost generic equivalents containing Fentanyl are available — ask your pharmacist.
Is Subsys available over the counter?
No. Subsys is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
What forms does Subsys come in?
Subsys is currently marketed as spray/inhaler, per the FDA's National Drug Code Directory.
What class of drug is Subsys?
Subsys is classified as opioid agonist, per the FDA's Established Pharmacologic Class.
Is Subsys FDA-registered?
Subsys is on record with the U.S. FDA under application number NDA202788. You can verify this on its official FDA label.

Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.

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