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DURAMORPH PF vs SUBSYS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. DURAMORPH PF and SUBSYS are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

70/100
New

Pharmacy pays

$2.61 /mL
$9.51 /mL

Type

RX
RX

Active ingredient

MORPHINE SULFATE
FENTANYL

Manufacturer

Dosage forms

Injectable, Solution
Spray/Inhaler

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

Half-life

about 2 hours

Treats

Dyspnea, Intractable Pain
Pain

Frequently asked questions

Which is cheaper, Duramorph Pf or Subsys?

Duramorph Pf costs pharmacies less to acquire — about $2.61 vs $9.51 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Duramorph Pf and Subsys?

Duramorph Pf contains Morphine Sulfate, while Subsys contains Fentanyl — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.