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roxicet 5/500

Roxicet 5/500 is a combination medicine containing Acetaminophen and Oxycodone Hydrochloride.

Acetaminophen and Oxycodone Hydrochloride · by Roxane

Generic of Xartemis XR

Not yet rated· sourced from the FDA label
Rated against independent regulatory sources·Last updated August 21, 2026·How we rate
Verified againstopenFDANIH DailyMedRxClass

Key facts

Active ingredient
Acetaminophen and Oxycodone Hydrochloride
Form
Tablet
Strength
Acetaminophen 500MG; Oxycodone Hydrochloride 5MG
Type
Prescription (Rx)
Brand or generic
Generic
Manufacturer
Roxane
Half-life
about 3.5 to 4 hours (how long it stays in your system)
What the pharmacy pays
~$0.03 per ml — not your price
FDA application
ANDA089775
Availability
Discontinued (per FDA)

How long does Acetaminophen and Oxycodone Hydrochloride stay in your body?

The elimination half-life of acetaminophen and oxycodone hydrochloride is about 3.5 to 4 hours — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. This is the elimination half-life for immediate-release oxycodone in adults with normal organ function; extended/controlled-release products act longer, and in kidney or liver impairment oxycodone concentrations run higher and clearance is reduced. The main metabolites (noroxycodone, oxymorphone) are not longer-acting than the parent drug for immediate-release oxycodone.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: OXYCODONE HYDROCHLORIDE tablet — DailyMed.

Dosage forms

Tablet

The forms currently marketed in the U.S., per the FDA National Drug Code Directory.

Ways to save

Ask for the generic

Same active ingredient, far cheaper. Is there a generic? →

Request a 90-day supply

Bulk fills usually lower the per-dose price vs monthly refills.

Use copay cards

Manufacturer copay cards & patient-assistance programs — especially for brand drugs.

Compare alternatives

A same-class option may cost less. See alternatives →

Frequently asked questions

How much does Roxicet 5/500 cost?
Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $0.03 per ml, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
Is there a coupon or discount for Roxicet 5/500?
pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Roxicet 5/500. To pay less, Roxicet 5/500 is already a generic — usually the lowest-cost version — so the main levers are comparing cash prices between pharmacies and using a pharmacy discount-card service. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
Who makes Roxicet 5/500?
Roxicet 5/500 is marketed by Roxane. You can see Roxane's full profile, rating, and other products on pharmaranks.
Is Roxicet 5/500 a brand-name or generic drug?
Roxicet 5/500 is a generic medication; its active ingredient is Acetaminophen and Oxycodone Hydrochloride. Generics contain the same active ingredient as the brand-name original and are usually lower cost.
Is Roxicet 5/500 available over the counter?
No. Roxicet 5/500 is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
What forms does Roxicet 5/500 come in?
Roxicet 5/500 is currently marketed as tablet, per the FDA's National Drug Code Directory.
Is Roxicet 5/500 FDA-registered?
Roxicet 5/500 is on record with the U.S. FDA under application number ANDA089775. You can verify this on its official FDA label.
Has Roxicet 5/500 been recalled by the FDA?
Roxicet 5/500 has no FDA recalls recorded under its own application in the openFDA enforcement database. Its recall-safety score reflects its manufacturer's overall recall record. This is general reference, not medical advice — check the FDA recall database for the latest alerts.
Is Roxicet 5/500 safe?
There's no single safe-or-not verdict, and we don't yet have a composite recall-safety score for Roxicet 5/500. Review its FDA-label side effects and warnings below, and always consult a licensed professional.

Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.

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