palladone

How long does Hydromorphone Hydrochloride stay in your body?

The elimination half-life of hydromorphone hydrochloride is about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. These are the terminal (elimination) values the label gives, not a distribution phase. No longer-lasting active metabolite: the label states plainly that "the analgesic activity of hydromorphone hydrochloride is due to the parent drug, hydromorphone." Over 95% of a dose is converted to hydromorphone-3-glucuronide (plus minor 6-hydroxy reduction metabolites), which the label does not describe as analgesically active. Hydromorphone is not a prodrug. Kidney impairment: the drug is cleared more slowly — in the label's renal study, severe impairment (CLcr under 30 mL/min) gave a terminal half-life of about 40 hours versus about 15 hours in people with normal kidneys, and exposure rose 2-fold in moderate and 3-fold in severe impairment. Note the label's own inconsistency: that study's "normal kidney" comparator (about 15 hours) is much longer than the roughly 2.3-2.8 hours reported elsewhere in the same label, likely because of longer blood sampling; the label prints both without reconciling them, so treat the ~40 vs ~15 hour figures as a relative comparison within that one study rather than as the everyday number. Liver impairment: moderate impairment (Child-Pugh B) raised exposure about 4-fold; the label does not report a half-life for it, and severe impairment was never studied. Older adults: the label says age has no effect on hydromorphone pharmacokinetics. This is elimination from blood, not a drug-test detection window (metabolites stay detectable much longer), and it is not dosing guidance.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: HYDROMORPHONE HYDROCHLORIDE tablet - FDA label, Section 12.3 Pharmacokinetics (DailyMed).

Frequently asked questions

What does Palladone treat?

Palladone (Hydromorphone Hydrochloride) may be used to treat cough, postoperative pain, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.

How does Palladone work?

Palladone is a opioid agonist. Opioid agonists bind opioid receptors (mainly mu receptors) on nerves in the brain and spinal cord, dampening the release of pain-signaling chemicals so fewer pain messages reach the brain, which relieves moderate to severe pain.

How much does Palladone cost?

Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $0.57 per ml, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins. Pharmacies pay less for a same-class option, Imodium A-D — about $0.05 on the same basis.

Is there a coupon or discount for Palladone?

pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Palladone. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.

Who makes Palladone?

Palladone is marketed by Purdue Pharma LP. You can see Purdue Pharma LP's full profile, rating, and other products on pharmaranks.

Is Palladone a brand-name or generic drug?

Palladone is a brand-name product with the active ingredient Hydromorphone Hydrochloride. Lower-cost generic equivalents containing Hydromorphone Hydrochloride are available — ask your pharmacist.

Is Palladone available over the counter?

No. Palladone is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.

What forms does Palladone come in?

Palladone is currently marketed as capsule, extended release, per the FDA's National Drug Code Directory.

What class of drug is Palladone?

Palladone is classified as opioid agonist, per the FDA's Established Pharmacologic Class.

Is Palladone FDA-registered?

Palladone is on record with the U.S. FDA under application number NDA021044. You can verify this on its official FDA label.