METHADONE HYDROCHLORIDE vs PALLADONE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. METHADONE HYDROCHLORIDE and PALLADONE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	METHADONE HYDROCHLORIDE	PALLADONE
Rating	72/100	New
Pharmacy pays	$0.18 /mL	$0.57 /mL
Type	RX	RX
Active ingredient	METHADONE HYDROCHLORIDE	HYDROMORPHONE HYDROCHLORIDE
Manufacturer	Hikma	Purdue Pharma LP
Dosage forms	Injectable, Solution, Tablet	Capsule, extended release
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	Boxed warning	None
Half-life	about 8 to 59 hours (terminal/elimination half-life; a very wide range)	about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid
Treats	Opioid-Related Disorders, Intractable Pain	Cough, Postoperative Pain

methadone hydrochloride palladone

Rating

72/100

New

Pharmacy pays

$0.18 /mL

$0.57 /mL

Type

Active ingredient

METHADONE HYDROCHLORIDE

HYDROMORPHONE HYDROCHLORIDE

Manufacturer

Hikma

Purdue Pharma LP

Dosage forms

Injectable, Solution, Tablet

Capsule, extended release

Drug class

Opioid Agonist

Boxed warning

None

Half-life

about 8 to 59 hours (terminal/elimination half-life; a very wide range)

about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid

Treats

Opioid-Related Disorders, Intractable Pain

Cough, Postoperative Pain

Frequently asked questions

Which is cheaper, Methadone Hydrochloride or Palladone?

Methadone Hydrochloride costs pharmacies less to acquire — about $0.18 vs $0.57 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Methadone Hydrochloride and Palladone?

Methadone Hydrochloride contains Methadone Hydrochloride, while Palladone contains Hydromorphone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.