miostat
Miostat (Carbachol) is a cholinergic receptor agonist used to treat Glaucoma.
Carbachol · by Alcon
Key facts
- Active ingredient
- Carbachol
- Drug class
- Cholinergic Receptor Agonist
- Form
- Solution
- Strength
- Carbachol 0.01%
- Type
- Prescription (Rx)
- Brand or generic
- Brand-name
- May treat
- glaucoma
- Manufacturer
- Alcon
- FDA application
- NDA016968
What is Miostat?
From the FDA label:MIOSTAT™ (carbachol intraocular solution, USP) 0.01% is a sterile balanced salt solution of carbachol for intraocular injection. The active ingredient is represented by the chemical structure: Established Name: Carbachol Chemical Name: Ethanaminium, 2-[(aminocarbonyl)oxy]-N,N,Ntrimethyl-, chloride. Molecular Formula: C 6 H 15 CIN 2 O 2 Molecular Weight: 182.65 Each mL of MIOSTAT™ (carbachol intraocular solution, USP) 0.01% contains: Active: carbachol 0.01%. Inactives: sodium chloride 0.64%, potassium chloride 0.075%, calcium chloride dehydrate 0.048%, magnesium chloride hexahydrate 0.03%, sodium acetate trihydrate 0.39%, sodium citrate dihydrate 0.17%, sodium hydroxide and/or hydrochloric acid (to adjust pH) and Water for Injection. pH range is 6.5-7.5. chemical
How to use
Aseptically remove the sterile vial from the blister package by peeling the backing paper and dropping the vial onto a sterile tray. Withdraw the contents into a dry sterile syringe, and replace the needle with an atraumatic cannula prior to intraocular instillation. No more than one-half milliliter should be gently instilled into the anterior chamber for the production of satisfactory miosis. It may be instilled before or after securing sutures. Miosis is usually maximal within two to five minutes after application.
Side effects
Ocular: Corneal clouding, persistent bullous keratopathy, retinal detachment and postoperative iritis following cataract extraction have been reported. Systemic: Side effects such as flushing, sweating, epigastric distress, abdominal cramps, tightness in urinary bladder, and headache have been reported with topical or systemic application of carbachol. The following additional reactions have been identified during post-approval use of MIOSTAT (carbachol intraocular solution, USP) 0.01% in clinical practice. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. The reactions, which have been chosen for inclusion due to either their seriousness, frequency of reporting, possible causal connection to MIOSTAT, or a combination of these factors, include: corneal edema, drug effect prolonged (miosis), eye inflammation, eye pain, intraocular pressure increased, ocular hyperemia, vision blurred, visual impairment, and vomiting.
Warnings
Important safety information
For single-dose intraocular use only. Discard unused portion. Intraocular carbachol 0.01% should be used with caution in patients with acute cardiac failure, bronchial asthma, peptic ulcer, hyperthyroidism, G.I. spasm, urinary tract obstruction and Parkinson's disease. The vial stopper contains natural rubber (latex) which may cause severe allergic reactions.
Who should not take Miostat
Should not be used in those persons showing hypersensitivity to any of the components of this preparation.
Drug class
How this class works, per Muscarinic Agonists - StatPearls - NCBI Bookshelf.
May treat (source: NIH RxClass)
Dosage forms
Solution
The forms currently marketed in the U.S., per the FDA National Drug Code Directory.
Ways to save
Ask for the generic
Same active ingredient, far cheaper. Is there a generic? →
Request a 90-day supply
Bulk fills usually lower the per-dose price vs monthly refills.
Use copay cards
Manufacturer copay cards & patient-assistance programs — especially for brand drugs.
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Frequently asked questions
- What does Miostat treat?
- Miostat (Carbachol) may be used to treat glaucoma, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
- How does Miostat work?
- Miostat is a cholinergic receptor agonist. Cholinergic receptor agonists mimic acetylcholine and switch on its receptors, triggering the body's "rest and digest" responses. This boosts effects like saliva and tear flow, bladder and bowel emptying, and pupil constriction.
- Is there a coupon or discount for Miostat?
- pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Miostat. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
- Who makes Miostat?
- Miostat is marketed by Alcon. You can see Alcon's full profile, rating, and other products on pharmaranks.
- Is Miostat a brand-name or generic drug?
- Miostat is a brand-name product with the active ingredient Carbachol.
- Is Miostat available over the counter?
- No. Miostat is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
- What forms does Miostat come in?
- Miostat is currently marketed as solution, per the FDA's National Drug Code Directory.
- What class of drug is Miostat?
- Miostat is classified as cholinergic receptor agonist, per the FDA's Established Pharmacologic Class.
- Is Miostat FDA-registered?
- Miostat is on record with the U.S. FDA under application number NDA016968. You can verify this on its official FDA label.
- Is Miostat safe?
- There's no single safe-or-not verdict, and we don't yet have a composite recall-safety score for Miostat. Review its FDA-label side effects and warnings below, and always consult a licensed professional.
- What are the side effects of Miostat?
- Miostat's side effects are taken directly from its FDA label. From the label: Ocular: Corneal clouding, persistent bullous keratopathy, retinal detachment and postoperative iritis following cataract extraction have been reported. Systemic: Side effects such as flushing, sweating, epigastric distress, abdominal cramps, tightness in urinary bladder,… Both common and serious reactions are documented in full on this page. This is general reference from the FDA, not medical advice — always consult a professional.
Clinical content sourced from the FDA label via openFDA (U.S. FDA). View the FDA label on DailyMed → Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.
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