grape seed extract

Grape seed extract is a dietary supplement derived from the seeds of wine grapes (Vitis vinifera). It concentrates plant compounds known as proanthocyanidins. It is available as oral capsules and is also used as an ingredient in some products applied to the skin.

The evidence is limited and not conclusive. NCCIH summarizes a 2020 review suggesting grape seed extract may have favorable effects on LDL ("bad") cholesterol and triglycerides, but not on total or HDL cholesterol; NCCIH cautions these conclusions "should not be considered definite because the studies were small," and that product composition varied between studies. A 2022 review reportedly found a reduction in diastolic (lower-number) blood pressure but not systolic, with inconsistency across studies. For wound healing and tooth decay, the supportive findings come largely from laboratory or experimental models; NCCIH indicates there has not been enough research in people to determine whether grape seed extract is helpful for these uses.

NCCIH does not establish a standard or proven dose for grape seed extract, and product strengths vary widely. Because there is no government-recommended dosage, do not assume that a higher amount is better. Speak with your health care provider before starting grape seed extract to discuss whether it is suitable for you and, if so, what amount might be reasonable for your situation.

NCCIH describes grape seed extract as generally well tolerated when taken by mouth or applied to the skin. However, little is known about its safety during pregnancy or while breastfeeding, so people who are pregnant or nursing should be especially cautious. As with any supplement, discuss any complementary health approaches you use with your health care providers.

NCCIH characterizes grape seed extract as generally well tolerated when taken orally or used on the skin, and its overview does not list specific common side effects. Even so, individual reactions can occur; stop use and contact a clinician if you experience an adverse reaction such as a rash, stomach upset, or other unexpected symptoms.

Grape seed extract, like other herbal products, may interact with medications. NCCIH advises anyone taking any kind of medicine to consult their health care provider before using grape seed extract, because certain herb-drug combinations can be harmful. The specific interactions of grape seed extract are not well characterized, which is another reason to check with a provider first.