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differin epiduo acne gel (adapalene and benzoyl peroxide)

Differin Epiduo Acne Gel (Adapalene and Benzoyl Peroxide) is a combination medicine containing Adapalene, Benzoyl Peroxide, Adapalene, and Benzoyl Peroxide.

Adapalene, Benzoyl Peroxide and Adapalene and Benzoyl Peroxide · by Galderma Laboratories, L.P

Not yet rated· sourced from the FDA label
Rated against independent regulatory sources·Last updated August 22, 2026·How we rate
Verified againstopenFDANIH DailyMedRxClass

Key facts

Active ingredient
Adapalene, Benzoyl Peroxide and Adapalene and Benzoyl Peroxide
Form
Topical
Strength
ADAPALENE, Benzoyl Peroxide 15G · ADAPALENE, Benzoyl Peroxide 30G · ADAPALENE, Benzoyl Peroxide 45G
Type
Prescription (Rx)
Brand or generic
Brand-name
FDA application
NDA220736

What is Differin Epiduo Acne Gel (Adapalene and Benzoyl Peroxide)?

From the FDA label:Use For the treatment of acne

How to use

Directions Adults and children 12 years of age and older: use once daily clean the skin gently and pat dry before applying the product cover the entire affected area with a thin layer. For example, if your acne is on the face, apply the product to the entire face. applying more than directed will not provide faster or better results, but may worsen skin irritation. if going outside, apply sunscreen after using this product. If irritation or sensitivity develops, stop use of both products and ask a doctor. Children under 12 years of age: do not use Other information store at 20°C to 25°C (68°F to 77°F) protect from freezing protect from light and keep away from heat

Warnings

Important safety information

For external use only

Dosage forms

Topical

The forms currently marketed in the U.S., per the FDA National Drug Code Directory.

Ways to save

Ask for the generic

Same active ingredient, far cheaper. Is there a generic? →

Request a 90-day supply

Bulk fills usually lower the per-dose price vs monthly refills.

Use copay cards

Manufacturer copay cards & patient-assistance programs — especially for brand drugs.

Compare alternatives

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Frequently asked questions

Is there a coupon or discount for Differin Epiduo Acne Gel (Adapalene and Benzoyl Peroxide)?
pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Differin Epiduo Acne Gel (Adapalene and Benzoyl Peroxide). To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
Who makes Differin Epiduo Acne Gel (Adapalene and Benzoyl Peroxide)?
Differin Epiduo Acne Gel (Adapalene and Benzoyl Peroxide) is marketed by Galderma Laboratories, L.P. You can see Galderma Laboratories, L.P's full profile, rating, and other products on pharmaranks.
Is Differin Epiduo Acne Gel (Adapalene and Benzoyl Peroxide) a brand-name or generic drug?
Differin Epiduo Acne Gel (Adapalene and Benzoyl Peroxide) is a brand-name product with the active ingredient Adapalene, Benzoyl Peroxide and Adapalene and Benzoyl Peroxide.
Is Differin Epiduo Acne Gel (Adapalene and Benzoyl Peroxide) available over the counter?
No. Differin Epiduo Acne Gel (Adapalene and Benzoyl Peroxide) is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
What forms does Differin Epiduo Acne Gel (Adapalene and Benzoyl Peroxide) come in?
Differin Epiduo Acne Gel (Adapalene and Benzoyl Peroxide) is currently marketed as topical, per the FDA's National Drug Code Directory.
Is Differin Epiduo Acne Gel (Adapalene and Benzoyl Peroxide) FDA-registered?
Differin Epiduo Acne Gel (Adapalene and Benzoyl Peroxide) is on record with the U.S. FDA under application number NDA220736. You can verify this on its official FDA label.
Has Differin Epiduo Acne Gel (Adapalene and Benzoyl Peroxide) been recalled by the FDA?
Differin Epiduo Acne Gel (Adapalene and Benzoyl Peroxide) has no FDA recalls recorded under its own application in the openFDA enforcement database. Its recall-safety score reflects its manufacturer's overall recall record. This is general reference, not medical advice — check the FDA recall database for the latest alerts.
Is Differin Epiduo Acne Gel (Adapalene and Benzoyl Peroxide) safe?
There's no single safe-or-not verdict, and we don't yet have a composite recall-safety score for Differin Epiduo Acne Gel (Adapalene and Benzoyl Peroxide). Review its FDA-label side effects and warnings below, and always consult a licensed professional.

Clinical content sourced from the FDA label via openFDA (U.S. FDA). View the FDA label on DailyMed → Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.

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