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DIFFERIN EPIDUO ACNE GEL (ADAPALENE AND BENZOYL PEROXIDE) vs RETIN-A

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 7, 2026·How we rate

Possible drug interaction. DIFFERIN EPIDUO ACNE GEL (ADAPALENE AND BENZOYL PEROXIDE) and RETIN-A are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

72/100
74/100

Pharmacy pays

—
$1.05 /g

Type

RX
RX

Active ingredient

ADAPALENE, BENZOYL PEROXIDE AND ADAPALENE AND BENZOYL PEROXIDE
TRETINOIN

Dosage forms

Topical
Topical

Drug class

—
Retinoid

Boxed warning

None
None

Treats

—
Acne Vulgaris, Facial Dermatoses, Acute Promyelocytic Leukemia

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Frequently asked questions

Which is better-rated, Differin Epiduo Acne Gel (Adapalene and Benzoyl Peroxide) or Retin-A?

By our independent rating, Retin-A scores higher — 3.7 vs 3.6 out of 5 for Differin Epiduo Acne Gel (Adapalene and Benzoyl Peroxide). Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Differin Epiduo Acne Gel (Adapalene and Benzoyl Peroxide) and Retin-A?

Differin Epiduo Acne Gel (Adapalene and Benzoyl Peroxide) contains Adapalene, Benzoyl Peroxide and Adapalene and Benzoyl Peroxide, while Retin-A contains Tretinoin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.