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climara pro

Climara Pro is a combination medicine containing Estradiol and Levonorgestrel.

Estradiol and Levonorgestrel · by Berlex Labs

Not yet rated· sourced from the FDA label
Rated against independent regulatory sources·Last updated June 7, 2026·How we rate
Verified againstopenFDANIH DailyMedRxClass

Key facts

Active ingredient
Estradiol and Levonorgestrel
Form
Patch
Strength
Estradiol 0.045MG
Type
Prescription (Rx)
Brand or generic
Brand-name
Manufacturer
Berlex Labs
Half-life
about 36 hours (36 ± 13 hours at steady state) (how long it stays in your system)
What the pharmacy pays
~$6.64 per gm — not your price
FDA application
NDA021885

How long does Estradiol and Levonorgestrel stay in your body?

The elimination half-life of estradiol and levonorgestrel is about 36 hours (36 ± 13 hours at steady state) — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. This is the terminal elimination half-life stated directly for levonorgestrel; the label reports no active metabolite that outlasts the parent, and levonorgestrel is not a prodrug. The number comes from a levonorgestrel/ethinyl estradiol combination oral-contraceptive label (Aviane), where it is attributed specifically to the levonorgestrel component; the single-ingredient OTC emergency-contraceptive labels do not state a half-life. On populations: the label says no formal studies evaluated hepatic or renal impairment, but cautions that steroid hormones may be poorly metabolized in patients with impaired liver function; it notes no apparent pharmacokinetic differences across races, and states nothing about older adults.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: Aviane (levonorgestrel and ethinyl estradiol) label — DailyMed, Clinical Pharmacology / Pharmacokinetics.

Dosage forms

Patch

The forms currently marketed in the U.S., per the FDA National Drug Code Directory.

Ways to save

Ask for the generic

Same active ingredient, far cheaper. Is there a generic? →

Request a 90-day supply

Bulk fills usually lower the per-dose price vs monthly refills.

Use copay cards

Manufacturer copay cards & patient-assistance programs — especially for brand drugs.

Compare alternatives

A same-class option may cost less. See alternatives →

Frequently asked questions

How much does Climara Pro cost?
Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $6.64 per gm, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
Is there a coupon or discount for Climara Pro?
pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Climara Pro. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
Who makes Climara Pro?
Climara Pro is marketed by Berlex Labs. You can see Berlex Labs's full profile, rating, and other products on pharmaranks.
Is Climara Pro a brand-name or generic drug?
Climara Pro is a brand-name product with the active ingredient Estradiol and Levonorgestrel.
Is Climara Pro available over the counter?
No. Climara Pro is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
What forms does Climara Pro come in?
Climara Pro is currently marketed as patch, per the FDA's National Drug Code Directory.
Is Climara Pro FDA-registered?
Climara Pro is on record with the U.S. FDA under application number NDA021885. You can verify this on its official FDA label.

Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.

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