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CLIMARA PRO vs RETIN-A

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 8, 2026·How we rate

Possible drug interaction. CLIMARA PRO and RETIN-A are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
74/100

Pharmacy pays

$6.64 /g
$1.05 /g

Type

RX
RX

Active ingredient

ESTRADIOL AND LEVONORGESTREL
TRETINOIN

Dosage forms

Patch
Topical

Drug class

—
Retinoid

Boxed warning

None
None

Half-life

about 36 hours (36 ± 13 hours at steady state)
—

Treats

—
Acne Vulgaris, Facial Dermatoses, Acute Promyelocytic Leukemia

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Frequently asked questions

Which is cheaper, Climara Pro or Retin-A?

Retin-A costs pharmacies less to acquire — about $1.05 vs $6.64 per gm, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Climara Pro and Retin-A?

Climara Pro contains Estradiol and Levonorgestrel, while Retin-A contains Tretinoin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.