cefuroxime and dextrose in duplex container
Cefuroxime and Dextrose in Duplex Container (Cefuroxime Sodium) is a cephalosporin antibacterial used to treat Infectious Bone Diseases, Escherichia Coli Infections, Gonorrhea, Haemophilus Infections.
Cefuroxime Sodium · by B Braun
Available as a generic: Cefuroxime Sodium
Key facts
- Active ingredient
- Cefuroxime Sodium
- Drug class
- Cephalosporin Antibacterial
- Form
- Injectable
- Strength
- Cefuroxime Sodium EQ 1.5GM BASE/VIAL · Cefuroxime Sodium EQ 750MG BASE/VIAL
- Type
- Prescription (Rx)
- Brand or generic
- Brand-name
- Manufacturer
- B Braun
- FDA application
- NDA050780
- Availability
- Discontinued (per FDA)
What is Cefuroxime and Dextrose in Duplex Container?
From the FDA label:Cefuroxime for Injection USP and Dextrose Injection USP is a sterile, nonpyrogenic, single use, packaged combination of Cefuroxime Sodium USP (crystalline) and Dextrose Injection USP (diluent) in the DUPLEX® sterile container. The DUPLEX® Container is a flexible dual chamber container. The drug chamber is filled with sterile crystalline Cefuroxime for Injection USP, a semi-synthetic, broad-spectrum, cephalosporin antibacterial for parenteral administration. It is the sodium salt of (6 R ,7 R )-7-[2-(2-furyl)glyoxylamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate, 7 2 -( Z )-( O -methyloxime), carbamate (ester). Cefuroxime Sodium USP has the following structural formula: The empirical formula is C 16 H 15 N 4 NaO 8 S, representing a molecular weight of 446.4. Cefuroxime contains approximately 54.2 mg (2.4 mEq) of sodium per gram of cefuroxime activity. The diluent chamber contains Dextrose Injection USP. The concentration of Hydrous Dextrose USP has been adjusted to render the reconstituted drug product iso-osmotic. Dextrose Injection USP is sterile, nonpyrogenic, and contains no bacteriostatic or antimicrobial agents. Hydrous Dextrose USP has the following structural (molecular) formula: The molecular weight of Hydrous Dextrose USP is 198.17. Dextrose hydrous USP has been added to the diluent to adjust osmolality (approximately 2.05 g and 1.45 g…
How to use
This product is intended for intravenous administration only. Dosage: Adults: The usual adult dosage range for cefuroxime is 750 mg to 1.5 grams every 8 hours, usually for 5 to 10 days. In uncomplicated urinary tract infections, skin and skin-structure infections, disseminated gonococcal infections, and uncomplicated pneumonia, a 750 mg dose every 8 hours is recommended. In severe or complicated infections, a 1.5 gram dose every 8 hours is recommended. In bone and joint infections, a 1.5 gram dose every 8 hours is recommended. In clinical trials, surgical intervention was performed when indicated as an adjunct to cefuroxime therapy. A course of oral antibacterials was administered when appropriate following the completion of parenteral administration of cefuroxime. In life-threatening infections or infections due to less susceptible organisms, 1.5 grams every 6 hours may be required. In bacterial meningitis, the dosage should not exceed 3 grams every 8 hours. For preventive use for clean-contaminated or potentially contaminated surgical procedures, a 1.5 gram dose administered intravenously just before surgery (approximately one-half to 1 hour before the initial incision) is recommended. Thereafter, give 750 mg intravenously every 8 hours when the procedure is prolonged. For preventive use during open heart surgery, a 1.5 gram dose administered intravenously at the induction…
Side effects
Cefuroxime is generally well tolerated. The most common adverse effects have been local reactions following IV administration. Other adverse reactions have been encountered only rarely. Local Reactions: Thrombophlebitis has occurred with IV administration in 1 in 60 patients. Gastrointestinal: Gastrointestinal symptoms occurred in 1 in 150 patients and included diarrhea (1 in 220 patients) and nausea (1 in 440 patients). The onset of pseudomembranous colitis may occur during or after antibacterial treatment (see WARNINGS ). Hypersensitivity Reactions: Hypersensitivity reactions have been reported in fewer than 1% of the patients treated with cefuroxime and include rash (1 in 125). Pruritus, urticaria, and positive Coombs' test each occurred in fewer than 1 in 250 patients, and, as with other cephalosporins, rare cases of anaphylaxis, drug fever, erythema multiforme, interstitial nephritis, toxic epidermal necrolysis, and Stevens-Johnson syndrome have occurred. Blood: A decrease in hemoglobin and hematocrit has been observed in 1 in 10 patients and transient eosinophilia in 1 in 14 patients. Less common reactions seen were transient neutropenia (fewer than 1 in 100 patients) and leukopenia (1 in 750 patients). A similar pattern and incidence were seen with other cephalosporins used in controlled studies. As with other cephalosporins, there have been rare reports of…
Warnings
Important safety information
Clostridioides difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including Cefuroxime for Injection USP and Dextrose Injection USP, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. difficile . C. difficile produces toxins A and B which contribute to the development of CDAD. Hypertoxin producing strains of C. difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy. CDAD must be considered in all patients who present with diarrhea following antibacterial use. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents. If CDAD is suspected or confirmed, ongoing antibacterial use not directed against C. difficile may need to be discontinued. Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C. difficile , and surgical evaluation should be instituted as clinically indicated.
Who should not take Cefuroxime and Dextrose in Duplex Container
Cefuroxime for Injection USP and Dextrose Injection USP is contraindicated in patients with known allergy to the cephalosporin group of antibacterials. Solutions containing dextrose may be contraindicated in patients with hypersensitivity to corn products.
Overdose — what happens if you take too much
Overdosage of cephalosporins can cause cerebral irritation leading to convulsions. Serum levels of cefuroxime can be reduced by hemodialysis and peritoneal dialysis.
U.S. Poison Control: call or text 1-800-222-1222 (free, 24/7). In an emergency call 911. From the FDA label; not medical advice.
Drug class
How this class works, per Cephalosporins - StatPearls - NCBI Bookshelf.
May treat (source: NIH RxClass)
- infectious bone diseases
- escherichia coli infections
- gonorrhea
- haemophilus infections
- impetigo
- klebsiella infections
See how Cefuroxime and Dextrose in Duplex Container ranks — best-rated cephalosporin antibacterial for:
Dosage forms
Injectable
The forms currently marketed in the U.S., per the FDA National Drug Code Directory.
Ways to save
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Frequently asked questions
- What does Cefuroxime and Dextrose in Duplex Container treat?
- Cefuroxime and Dextrose in Duplex Container (Cefuroxime Sodium) may be used to treat infectious bone diseases, escherichia coli infections, gonorrhea, haemophilus infections, impetigo, klebsiella infections, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
- How does Cefuroxime and Dextrose in Duplex Container work?
- Cefuroxime and Dextrose in Duplex Container is a cephalosporin antibacterial. Cephalosporins kill bacteria by blocking the proteins they use to build their cell walls. Without an intact wall, the bacterium cannot hold its shape and dies, which clears the infection.
- Is there a coupon or discount for Cefuroxime and Dextrose in Duplex Container?
- pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Cefuroxime and Dextrose in Duplex Container. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
- Who makes Cefuroxime and Dextrose in Duplex Container?
- Cefuroxime and Dextrose in Duplex Container is marketed by B Braun. You can see B Braun's full profile, rating, and other products on pharmaranks.
- Is Cefuroxime and Dextrose in Duplex Container a brand-name or generic drug?
- Cefuroxime and Dextrose in Duplex Container is a brand-name product with the active ingredient Cefuroxime Sodium. Lower-cost generic equivalents containing Cefuroxime Sodium are available — ask your pharmacist.
- Is Cefuroxime and Dextrose in Duplex Container available over the counter?
- No. Cefuroxime and Dextrose in Duplex Container is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
- What forms does Cefuroxime and Dextrose in Duplex Container come in?
- Cefuroxime and Dextrose in Duplex Container is currently marketed as injectable, per the FDA's National Drug Code Directory.
- What class of drug is Cefuroxime and Dextrose in Duplex Container?
- Cefuroxime and Dextrose in Duplex Container is classified as cephalosporin antibacterial, per the FDA's Established Pharmacologic Class.
- Is Cefuroxime and Dextrose in Duplex Container FDA-registered?
- Cefuroxime and Dextrose in Duplex Container is on record with the U.S. FDA under application number NDA050780. You can verify this on its official FDA label.
- Is Cefuroxime and Dextrose in Duplex Container safe?
- There's no single safe-or-not verdict, and we don't yet have a composite recall-safety score for Cefuroxime and Dextrose in Duplex Container. Review its FDA-label side effects and warnings below, and always consult a licensed professional.
- What are the side effects of Cefuroxime and Dextrose in Duplex Container?
- Cefuroxime and Dextrose in Duplex Container's side effects are taken directly from its FDA label. From the label: Cefuroxime is generally well tolerated. The most common adverse effects have been local reactions following IV administration. Other adverse reactions have been encountered only rarely. Local Reactions: Thrombophlebitis has occurred with IV administration in 1 in 60 patients.… Both common and serious reactions are documented in full on this page. This is general reference from the FDA, not medical advice — always consult a professional.
Clinical content sourced from the FDA label via openFDA (U.S. FDA). View the FDA label on DailyMed → Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.
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