What is hydrochlorothiazide?

Hydrochlorothiazide, USP is a diuretic and antihypertensive. It is the 3,4-dihydro derivative of chlorothiazide. It is chemically designated as 6-chloro-3,4-dihydro-2 H -1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide and has the following structural formula: Hydrochlorothiazide, USP is a white, or practically white, crystalline powder which is slightly soluble in water, freely soluble in sodium hydroxide solution, in n-butylamine, and in dimethylformamide; sparingly soluble in methanol; insoluble in ether, in chloroform, and in dilute mineral acids. The molecular formula is C 7 H 8 ClN 3 O 4 S 2 and the molecular weight is 297.74. INZIRQO (hydrochlorothiazide) is supplied in one strength as an off-white to light-brown colored powder for oral suspension. When reconstituted with 66 mL of water, the total volume of the suspension is 80 mL containing 10 mg/mL of hydrochlorothiazide, USP. In addition, INZIRQO contains the following inactive ingredients: anhydrous citric acid, caramel flavor (artificial flavor, caramel, maltodextrin, molasses, propylene glycol, salt and sucrose), cellulose, peppermint flavor (acacia and natural flavor), potassium sorbate, sucrose, talc and xanthan gum. structure

What kind of drug is hydrochlorothiazide?

The FDA classifies hydrochlorothiazide as a thiazide diuretic. If you are checking whether it is safe to combine with something else, the class is what matters — two drugs from the same class usually should not be stacked.

Can you take hydrochlorothiazide with other medicines?

It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run hydrochlorothiazide against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.

What brand names is hydrochlorothiazide sold under?

We track 5 hydrochlorothiazide-containing products in the U.S.: Inzirqo, Hydrochlorothiazide, Oretic, Esidrix and Microzide. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.

What forms does hydrochlorothiazide come in?

Across the brands we track, hydrochlorothiazide is currently marketed as powder, capsule and tablet, per the FDA's National Drug Code Directory. Each form is dosed differently — follow the label for the exact product you were prescribed.

Is there a generic hydrochlorothiazide?

Yes. Our catalog lists 1 generic hydrochlorothiazide product alongside the brand versions. A generic has the same active ingredient and must meet the FDA's bioequivalence standard; it usually costs less. Ask your pharmacist which one your plan covers.

Has hydrochlorothiazide been recalled?

The FDA's Enforcement database lists 4 recall records whose product description mentions hydrochlorothiazide. The most recent: Bisoprolol Fumarate and Hydrochlorothiazide tablets (Jan 21, 2026). A recall applies to specific lots, not to the drug as a whole — check the record for the affected lot numbers.

Hydrochlorothiazide: uses, dosing, side effects & brands

Hydrochlorothiazide is a thiazide diuretic sold in the U.S. under 5 brand and generic names, for edema, heart failure and hypertension. Below: what the FDA label says, every product that contains it, what the pills look like, and its recall record.

By the pharmaranks editorial teamReviewed against the FDA (openFDA label, NDC Directory & Enforcement) sourcesHow we research

Key facts

Drug class: Thiazide Diuretic
Treats: Edema, Heart Failure and Hypertension
Available as: Powder · Capsule · Tablet
Sold as: 5 products — Inzirqo, Hydrochlorothiazide and Oretic, and others
Prescription?: Prescription only
Generic available?: Yes
Typical price: about $1 for a 30-count supply

How hydrochlorothiazide is dosed

From the FDA label for Inzirqo (application NDA219141). Other hydrochlorothiazide products — different forms, different strengths — are dosed differently. Follow the label for the one you were prescribed.

For the treatment of hypertension in adults: The recommended initial dose in adults is 25 mg orally daily given as a single dose. As needed, increase the dose to 50 mg orally daily, given as a single or two divided doses(2.1). For the treatment of edema in adults: The recommended adult dosage is 25 mg to 100 mg orally daily as a single or divided dose. Consider intermittent therapy to reduce the risk of electrolyte imbalances, i.e., administration on alternate days or on 3 to 5 days each week (2.2). For the treatment of hypertension and edema in pediatric patients: The recommended pediatric dosage is 1 mg/kg to 2 mg/kg orally per day in single or two divided doses. Do not exceed 37.5 mg per day in patients less than 2 years of age or 100 mg per day in children 2 to less than 13 years of age. Patients less than 6 months of age may require doses up to 3 mg/kg orally per day in two divided doses (2.1, 2.2). 2.1 Recommended Dosage for the Treatment of Hypertension The recommended initial dose in adults is 25 mg orally daily given as a single dose. As needed, increase the dose to 50 mg orally daily, given as a single or two divided doses. Pediatric Patients: The recommended dose in pediatric patients is 1 to 2 mg/kg per day in one or two divided doses not to exceed 37.5 mg in patients less than 2 years of age and 100 mg in patients 2 to less than 13 years of age. In pediatric…

Hydrochlorothiazide side effects

The following adverse reactions with INZIRQO are described elsewhere: Impaired Renal Function [see Warnings and Precautions (5.1)] Electrolyte Abnormalities [see Warnings and Precautions (5.2)] Metabolic Disturbances [see Warnings and Precautions (5.3)] Systemic Lupus Erythematosus [see Warnings and Precautions (5.4)] Acute Angle-Closure Glaucoma and Acute Myopia [see Warnings and Precautions (5.5)] Adverse reactions include hypokalemia, hyponatremia, hypomagnesemia, hyperglycemia, hyperuricemia, hyperlipidemia and hypotension. See Adverse Reactions (6) To report SUSPECTED ADVERSE REACTIONS, contact ANI Pharmaceuticals, Inc. at 1-855-204-1431 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch . 6.1 Clinical Trials Experience The following adverse reactions have been reported and, within each category, are listed in order of decreasing severity. Body as a Whole: Weakness. Cardiovascular: Hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs). Gastrointestinal: Pancreatitis, jaundice (intrahepatic cholestatic jaundice), diarrhea, vomiting, sialadenitis, cramping, constipation, gastric irritation, nausea, anorexia. Hematologic: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia. Hypersensitivity: Anaphylactic reactions, necrotizing angiitis (vasculitis and cutaneous vasculitis),…

Every hydrochlorothiazide product we track (5)

Same active ingredient — different manufacturer, form, price and FDA recall record. That last one is what our independent score measures.

Hydrochlorothiazide products
#	Drug	Rating	Type	Form	Generic?	Typical price
1	Inzirqo	72/100	Prescription	Suspension	Generic	$1	View →
2	Hydrochlorothiazide	70/100	Prescription	Capsule	Generic

What hydrochlorothiazide pills look like

Imprint codes, colour and shape from the FDA’s labelling data. Match the imprint on your pill — or search any imprint.

Hydrochlorothiazide pill imprints
Imprint	Strength	Colour	Shape	Maker
U;128	25 mg	orange	round	—
T4	5 mg / 12.5 mg	white	oval	—
T;3	10 mg / 25 mg	pink	oval	—
VASE;10;25	10 mg / 25 mg	red	oval	—
C133	5 mg / 12.5 mg	white	round	—
C134	10 mg / 25 mg

Combination products containing hydrochlorothiazide

A combination is a different drug — different dosing, different warnings. It is listed here so you can find it, not so you can substitute it.

Hydrochlorothiazide recalls

From the FDA Enforcement database. A recall covers specific lots — not the drug as a whole.

Frequently asked questions

What is hydrochlorothiazide?: Hydrochlorothiazide, USP is a diuretic and antihypertensive. It is the 3,4-dihydro derivative of chlorothiazide. It is chemically designated as 6-chloro-3,4-dihydro-2 H -1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide and has the following structural formula: Hydrochlorothiazide, USP is a white, or practically white, crystalline powder which is slightly soluble in water, freely soluble in sodium hydroxide solution, in n-butylamine, and in dimethylformamide; sparingly soluble in methanol; insoluble in ether, in chloroform, and in dilute mineral acids. The molecular formula is C 7 H 8 ClN 3 O 4 S 2 and the molecular weight is 297.74. INZIRQO (hydrochlorothiazide) is supplied in one strength as an off-white to light-brown colored powder for oral suspension. When reconstituted with 66 mL of water, the total volume of the suspension is 80 mL containing 10 mg/mL of hydrochlorothiazide, USP. In addition, INZIRQO contains the following inactive ingredients: anhydrous citric acid, caramel flavor (artificial flavor, caramel, maltodextrin, molasses, propylene glycol, salt and sucrose), cellulose, peppermint flavor (acacia and natural flavor), potassium sorbate, sucrose, talc and xanthan gum. structure
What kind of drug is hydrochlorothiazide?: The FDA classifies hydrochlorothiazide as a thiazide diuretic. If you are checking whether it is safe to combine with something else, the class is what matters — two drugs from the same class usually should not be stacked.
Can you take hydrochlorothiazide with other medicines?: It depends on the medicine. We check it against the FDA labels rather than guessing: our interaction checker searches each drug's own label for the other and quotes what it says, naming the section it came from. Run hydrochlorothiazide against whatever else you take — and remember that a label not naming a drug is not the same as that combination being safe.
What brand names is hydrochlorothiazide sold under?: We track 5 hydrochlorothiazide-containing products in the U.S.: Inzirqo, Hydrochlorothiazide, Oretic, Esidrix and Microzide. They are the same active ingredient; they differ in form, manufacturer, price and FDA recall record.

Sources: FDA openFDA drug label, National Drug Code Directory, and Enforcement (recall) database. This page reproduces public FDA data and is not medical advice. Dosing is set by your prescriber.