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Best treatments for streptococcal infections

15 products may treat streptococcal infections, spanning FDA drug classes such as lincosamide antibacterial, oxazolidinone antibacterial, lipoglycopeptide antibacterial. The current highest-rated option is dalvance. Ranked below by our independent recall-safety rating (rated where FDA data exists) — not medical advice; always consult a professional.

Quick answer: Of the 15 drugs we list for streptococcal infections, 10 are available as lower-cost generics, spanning classes such as lincosamide antibacterial, oxazolidinone antibacterial, lipoglycopeptide antibacterial. They’re ranked by each drug’s FDA recall-safety record — not clinical effectiveness for streptococcal infections — so confirm the right choice with your prescriber.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Understanding streptococcal infections

"Streptococcal infections" refers to a group of illnesses caused by Streptococcus bacteria. There are several types, but two cause most infections in people: group A and group B (MedlinePlus). Group A strep commonly causes strep throat, scarlet fever, and the skin infection impetigo, and can also cause more serious illness including cellulitis, necrotizing fasciitis, and streptococcal toxic shock syndrome (MedlinePlus; CDC). Group B strep can cause blood infections, pneumonia, and meningitis in newborns, and urinary tract infections, blood infections, skin infections, and pneumonia in adults (MedlinePlus). Group A strep spreads when infected people talk, cough, or sneeze, and through contact with infected skin sores; some people carry the bacteria without symptoms yet can still spread it (CDC). Strep throat often begins with a sudden sore throat, pain when swallowing, and fever, sometimes with swollen neck lymph nodes and small red spots on the palate (CDC). Because clinical signs alone cannot reliably separate strep from a viral sore throat, providers confirm it with a rapid antigen detection test or a throat culture (CDC). This is general information, not medical advice.

First-line treatment

For group A streptococcal pharyngitis (strep throat), the CDC states that penicillin or amoxicillin is the antibiotic of choice; the Infectious Diseases Society of America (IDSA) likewise identifies penicillin or amoxicillin as the treatment of choice (CDC; IDSA). Treatment courses are typically about 10 days (CDC). According to the CDC, treating confirmed strep throat with antibiotics can shorten how long symptoms last, reduce the chance of spreading it to close contacts, and lower the risk of complications; in children, this includes reducing the risk of acute rheumatic fever (CDC). For people with a penicillin allergy, the CDC lists several alternative regimens, including a first-generation cephalosporin, clindamycin, azithromycin, or clarithromycin (CDC). A clinician confirms the diagnosis and individualizes the antibiotic choice and duration based on allergies and the specific infection. This is general information, not medical advice.

Top-rated picks for streptococcal infections: 1. Dalvance · 2. Sivextro · 3. Teflaro

Top-rated treatments for streptococcal infections, ranked by pharmaranks score
#DrugRatingPharmacy pays
172/100View →
272/100View →
372/100View →
470/100$0View →
570/100$0View →
664/100$0View →
764/100$0View →
864/100$0View →
964/100$1View →
1058/100$0View →

Full ranking · 15 treatments

ABBVIE logo

dalvance

PrescriptionFDA-sourced

72/100

Dalvance (Dalbavancin Hydrochloride) is a medication used to treat Infectious Skin Diseases, Staphylococcal Infections, Streptococcal Infections.

(6 data points)
skin diseases, infectiousstaphylococcal infectionsstreptococcal infections

Price varies

View details →

sivextro

PrescriptionFDA-sourced

72/100

Sivextro (Tedizolid Phosphate) is a medication used to treat Staphylococcal Infections, Streptococcal Infections, Bacterial Skin Diseases.

(4 data points)
staphylococcal infectionsstreptococcal infectionsskin diseases, bacterial

Price varies

View details →
ABBVIE logo

teflaro

PrescriptionFDA-sourced

72/100

Teflaro (Ceftaroline Fosamil) is a medication used to treat Escherichia Coli Infections, Klebsiella Infections, Pneumonia, Infectious Skin Diseases.

(6 data points)
escherichia coli infectionsklebsiella infectionspneumonia

Price varies

View details →
PADAGIS US logo
#1 of 7 in Lincosamide Antibacterial

clindesse

PrescriptionFDA-sourced

70/100

Clindesse (Clindamycin Phosphate) is a lincosamide antibacterial used to treat Acne Vulgaris, Actinomycetales Infections, Bacteroides Infections, Pneumocystis Pneumonia.

(3 data points)
lincosamide antibacterialacne vulgarisactinomycetales infections

Pharmacy pays

From ~$0.11· 6 forms
View details →
ORGANON logo
#1 of 7 in Lincosamide Antibacterial

xaciato

PrescriptionFDA-sourced

70/100

Xaciato (Clindamycin Phosphate) is a lincosamide antibacterial used to treat Acne Vulgaris, Actinomycetales Infections, Bacteroides Infections, Pneumocystis Pneumonia.

(1 data points)
lincosamide antibacterialacne vulgarisactinomycetales infections

Pharmacy pays

From ~$0.11· 6 forms
View details →
PFIZER logo
#3 of 7 in Lincosamide Antibacterial

cleocin

PrescriptionFDA-sourced

64/100

Cleocin (Clindamycin Phosphate) is a lincosamide antibacterial used to treat Acne Vulgaris, Actinomycetales Infections, Bacteroides Infections, Pneumocystis Pneumonia.

(61 data points)
lincosamide antibacterialacne vulgarisactinomycetales infections

Pharmacy pays

From ~$0.11· 6 forms
View details →

Frequently asked

What treats streptococcal infections?
Our catalog lists 15 products that may treat streptococcal infections, based on NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. They're rated where FDA recall-safety data exists; the current top-rated option is dalvance.
What is the best-rated treatment for streptococcal infections?
By our independent recall-safety rating — not an efficacy measure — dalvance ranks highest among the products we list for streptococcal infections. Always consult a professional.
How are these treatments ranked?
By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.
What types of drugs treat streptococcal infections?
Treatments for streptococcal infections span FDA drug classes including lincosamide antibacterial, oxazolidinone antibacterial, lipoglycopeptide antibacterial. Compare every option side by side, ranked by independent rating, above.

Treatment associations are derived from NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. This is general reference, not medical advice — always consult a licensed professional.

Sources

The clinical overview above is written from these authoritative public-health and medical-society sources, independently reviewed against each.