Best treatments for streptococcal infections
15 products may treat streptococcal infections, spanning FDA drug classes such as lincosamide antibacterial, oxazolidinone antibacterial, lipoglycopeptide antibacterial. The current highest-rated option is dalvance. Ranked below by our independent recall-safety rating (rated where FDA data exists) — not medical advice; always consult a professional.
Quick answer: Of the 15 drugs we list for streptococcal infections, 10 are available as lower-cost generics, spanning classes such as lincosamide antibacterial, oxazolidinone antibacterial, lipoglycopeptide antibacterial. They’re ranked by each drug’s FDA recall-safety record — not clinical effectiveness for streptococcal infections — so confirm the right choice with your prescriber.
Understanding streptococcal infections
"Streptococcal infections" refers to a group of illnesses caused by Streptococcus bacteria. There are several types, but two cause most infections in people: group A and group B (MedlinePlus). Group A strep commonly causes strep throat, scarlet fever, and the skin infection impetigo, and can also cause more serious illness including cellulitis, necrotizing fasciitis, and streptococcal toxic shock syndrome (MedlinePlus; CDC). Group B strep can cause blood infections, pneumonia, and meningitis in newborns, and urinary tract infections, blood infections, skin infections, and pneumonia in adults (MedlinePlus). Group A strep spreads when infected people talk, cough, or sneeze, and through contact with infected skin sores; some people carry the bacteria without symptoms yet can still spread it (CDC). Strep throat often begins with a sudden sore throat, pain when swallowing, and fever, sometimes with swollen neck lymph nodes and small red spots on the palate (CDC). Because clinical signs alone cannot reliably separate strep from a viral sore throat, providers confirm it with a rapid antigen detection test or a throat culture (CDC). This is general information, not medical advice.
First-line treatment
For group A streptococcal pharyngitis (strep throat), the CDC states that penicillin or amoxicillin is the antibiotic of choice; the Infectious Diseases Society of America (IDSA) likewise identifies penicillin or amoxicillin as the treatment of choice (CDC; IDSA). Treatment courses are typically about 10 days (CDC). According to the CDC, treating confirmed strep throat with antibiotics can shorten how long symptoms last, reduce the chance of spreading it to close contacts, and lower the risk of complications; in children, this includes reducing the risk of acute rheumatic fever (CDC). For people with a penicillin allergy, the CDC lists several alternative regimens, including a first-generation cephalosporin, clindamycin, azithromycin, or clarithromycin (CDC). A clinician confirms the diagnosis and individualizes the antibiotic choice and duration based on allergies and the specific infection. This is general information, not medical advice.
Top-rated picks for streptococcal infections: 1. Dalvance · 2. Sivextro · 3. Teflaro
| # | Drug | Rating | Type | Form | Class | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|---|
| 1 | 72/100 | Prescription | Injectable | — | No data | — | View → | |
| 2 | 72/100 | Prescription | Injectable | — | No data | — | View → | |
| 3 | 72/100 | Prescription | Solution | — | No data | — | View → | |
| 4 | 70/100 | Prescription | Topical | Lincosamide Antibacterial | Generic | $0 | View → | |
| 5 | 70/100 | Prescription | Topical | Lincosamide Antibacterial | Generic | $0 | View → | |
| 6 | 64/100 | Prescription | Topical | Lincosamide Antibacterial | Generic | $0 | View → | |
| 7 | 64/100 | Prescription | Capsule | Lincosamide Antibacterial | Generic | $0 | View → | |
| 8 | 64/100 | Prescription | Topical | Lincosamide Antibacterial | Generic | $0 | View → | |
| 9 | 64/100 | Prescription | Suspension | Oxazolidinone Antibacterial | Generic | $1 | View → | |
| 10 | 58/100 | Prescription | Injectable | Lincosamide Antibacterial | Generic | $0 | View → |
Narrow by drug class
Explore the class hubs: lincosamide antibacterial
Full ranking · 15 treatments
dalvance
PrescriptionFDA-sourced
Dalvance (Dalbavancin Hydrochloride) is a medication used to treat Infectious Skin Diseases, Staphylococcal Infections, Streptococcal Infections.
Price varies
sivextro
PrescriptionFDA-sourced
Sivextro (Tedizolid Phosphate) is a medication used to treat Staphylococcal Infections, Streptococcal Infections, Bacterial Skin Diseases.
Price varies
teflaro
PrescriptionFDA-sourced
Teflaro (Ceftaroline Fosamil) is a medication used to treat Escherichia Coli Infections, Klebsiella Infections, Pneumonia, Infectious Skin Diseases.
Price varies
clindesse
PrescriptionFDA-sourced
Clindesse (Clindamycin Phosphate) is a lincosamide antibacterial used to treat Acne Vulgaris, Actinomycetales Infections, Bacteroides Infections, Pneumocystis Pneumonia.
Pharmacy pays
From ~$0.11· 6 formsxaciato
PrescriptionFDA-sourced
Xaciato (Clindamycin Phosphate) is a lincosamide antibacterial used to treat Acne Vulgaris, Actinomycetales Infections, Bacteroides Infections, Pneumocystis Pneumonia.
Pharmacy pays
From ~$0.11· 6 formscleocin
PrescriptionFDA-sourced
Cleocin (Clindamycin Phosphate) is a lincosamide antibacterial used to treat Acne Vulgaris, Actinomycetales Infections, Bacteroides Infections, Pneumocystis Pneumonia.
Pharmacy pays
From ~$0.11· 6 forms- Cleocin Hydrochloride
- Cleocin T
- Zyvox
- Cleocin Phosphate
- Clindagel
- Clindamycin Hydrochloride
- Clindamycin Phosphate
- Kimyrsa
- Vibativ
Frequently asked
- What treats streptococcal infections?
- Our catalog lists 15 products that may treat streptococcal infections, based on NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. They're rated where FDA recall-safety data exists; the current top-rated option is dalvance.
- What is the best-rated treatment for streptococcal infections?
- By our independent recall-safety rating — not an efficacy measure — dalvance ranks highest among the products we list for streptococcal infections. Always consult a professional.
- How are these treatments ranked?
- By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.
- What types of drugs treat streptococcal infections?
- Treatments for streptococcal infections span FDA drug classes including lincosamide antibacterial, oxazolidinone antibacterial, lipoglycopeptide antibacterial. Compare every option side by side, ranked by independent rating, above.
Treatment associations are derived from NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. This is general reference, not medical advice — always consult a licensed professional.
Sources
The clinical overview above is written from these authoritative public-health and medical-society sources, independently reviewed against each.
- About Group A Strep, U.S. Centers for Disease Control and Prevention (CDC) ↗
- Clinical Guidance for Group A Streptococcal Pharyngitis, U.S. Centers for Disease Control and Prevention (CDC) ↗
- Streptococcal Infections, MedlinePlus / U.S. National Library of Medicine (NLM) ↗
- Clinical Practice Guideline for the Diagnosis and Management of Group A Streptococcal Pharyngitis (2012 Update), Infectious Diseases Society of America (IDSA) ↗