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Best treatments for relapsing-remitting multiple sclerosis

10 products may treat relapsing-remitting multiple sclerosis, spanning FDA drug classes such as sphingosine 1-phosphate receptor modulator, pyrimidine synthesis inhibitor. The current highest-rated option is fingolimod hydrochloride. Ranked below by our independent recall-safety rating (rated where FDA data exists) — not medical advice; always consult a professional.

Quick answer: Of the 10 drugs we list for relapsing-remitting multiple sclerosis, 4 are available as lower-cost generics, spanning classes such as sphingosine 1-phosphate receptor modulator, pyrimidine synthesis inhibitor. They’re ranked by each drug’s FDA recall-safety record — not clinical effectiveness for relapsing-remitting multiple sclerosis — so confirm the right choice with your prescriber.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Understanding relapsing-remitting multiple sclerosis

Multiple sclerosis (MS) is a disease of the central nervous system — the brain and spinal cord — thought to be an autoimmune condition in which the immune system mistakenly attacks myelin, the protective sheath around nerve fibers. This damage slows or blocks the signals traveling between the brain and the body. MS is most commonly diagnosed between ages 20 and 40 and affects women more often than men, though it can occur at any age. Symptoms vary widely and may include vision problems, muscle weakness, numbness or "pins and needles," trouble with balance and coordination, fatigue, and difficulties with thinking or memory. Many people have a relapsing course, in which symptoms flare and are then followed by remissions with reduced or no symptoms. There is no single specific test for MS; doctors use medical history, a neurological exam, MRI scans, and other tests to look for signs of nerve damage in different areas and at different times. There is no cure, but treatments can slow the disease and help control symptoms. Care is individualized and often combines medication with physical or occupational therapy. This is general information, not medical advice.

First-line treatment

For people with relapsing forms of MS, the standard approach is to start a disease-modifying therapy (DMT). The American Academy of Neurology's 2018 practice guideline (reaffirmed October 2024) found that several DMTs reduce the rate and risk of MS relapses and of new or enlarging lesions on MRI, and it takes a personalized approach — weighing each therapy's benefits and risks for the individual patient. Sudden flare-ups (relapses) are often treated separately with steroids (corticosteroids) to reduce inflammation and help nerves work better; steroids are more effective for the relapsing-remitting form. Additional medicines and rehabilitation address specific symptoms such as muscle spasms, bladder problems, fatigue, or mood. Because everyone's needs differ and the right treatment often changes over time, a clinician should guide and adjust the plan. This is general information, not medical advice.

Top-rated picks for relapsing-remitting multiple sclerosis: 1. Fingolimod Hydrochloride · 2. Aubagio · 3. Gilenya

Top-rated treatments for relapsing-remitting multiple sclerosis, ranked by pharmaranks score
#DrugRatingPharmacy pays
172/100$126View →
270/100$16View →
370/100$126View →
470/100View →
556/100$16View →
6Not yet ratedView →
7Not yet ratedView →
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Full ranking · 10 treatments

#1 of 3 in Sphingosine 1-phosphate Receptor Modulator

fingolimod hydrochloride

PrescriptionFDA-sourced

72/100

Fingolimod Hydrochloride is a sphingosine 1-phosphate receptor modulator used to treat Relapsing-Remitting Multiple Sclerosis.

(5 data points)
sphingosine 1-phosphate receptor modulatormultiple sclerosis, relapsing-remitting

Pharmacy pays

~$126.02 /30

View details →
SANOFI AVENTIS US logo

aubagio

Boxed warning

PrescriptionFDA-sourced

70/100

Aubagio (Teriflunomide) is a pyrimidine synthesis inhibitor used to treat Relapsing-Remitting Multiple Sclerosis.

(1 data points)
pyrimidine synthesis inhibitormultiple sclerosis, relapsing-remitting

Pharmacy pays

From ~$13.73/30· 2 forms
View details →
NOVARTIS logo
#2 of 3 in Sphingosine 1-phosphate Receptor Modulator

gilenya

PrescriptionFDA-sourced

70/100

Gilenya (Fingolimod Hydrochloride) is a sphingosine 1-phosphate receptor modulator used to treat Relapsing-Remitting Multiple Sclerosis.

(13 data points)
sphingosine 1-phosphate receptor modulatormultiple sclerosis, relapsing-remitting

Pharmacy pays

~$126.02 /30

View details →
NOVARTIS logo

mayzent

PrescriptionFDA-sourced

70/100

Mayzent (Siponimod) is a medication used to treat Chronic Progressive Multiple Sclerosis, Relapsing-Remitting Multiple Sclerosis.

(13 data points)
multiple sclerosis, chronic progressivemultiple sclerosis, relapsing-remitting

Price varies

View details →

teriflunomide

Boxed warning

PrescriptionFDA-sourced

56/100

Teriflunomide is a pyrimidine synthesis inhibitor used to treat Relapsing-Remitting Multiple Sclerosis.

(124 data points)
pyrimidine synthesis inhibitormultiple sclerosis, relapsing-remitting

Pharmacy pays

From ~$13.73/30· 2 forms
View details →

briumvi

PrescriptionFDA-sourced

New

Briumvi (Ublituximab-Xiiy) is a medication used to treat Demyelinating Diseases, Chronic Progressive Multiple Sclerosis, Relapsing-Remitting Multiple Sclerosis.

demyelinating diseasesmultiple sclerosis, chronic progressivemultiple sclerosis, relapsing-remitting

Price varies

View details →

Frequently asked

What treats relapsing-remitting multiple sclerosis?
Our catalog lists 10 products that may treat relapsing-remitting multiple sclerosis, based on NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. They're rated where FDA recall-safety data exists; the current top-rated option is fingolimod hydrochloride.
What is the best-rated treatment for relapsing-remitting multiple sclerosis?
By our independent recall-safety rating — not an efficacy measure — fingolimod hydrochloride ranks highest among the products we list for relapsing-remitting multiple sclerosis. Always consult a professional.
How are these treatments ranked?
By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.
What types of drugs treat relapsing-remitting multiple sclerosis?
Treatments for relapsing-remitting multiple sclerosis span FDA drug classes including sphingosine 1-phosphate receptor modulator, pyrimidine synthesis inhibitor. Compare every option side by side, ranked by independent rating, above.

Treatment associations are derived from NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. This is general reference, not medical advice — always consult a licensed professional.

Sources

The clinical overview above is written from these authoritative public-health and medical-society sources, independently reviewed against each.