Sphingosine 1-phosphate Receptor Modulator drugs compared

Compare all 5 Sphingosine 1-phosphate Receptor Modulator drugs side by side, used for conditions such as multiple sclerosis, relapsing-remitting, colitis, ulcerative. They share one FDA-defined mechanism but differ in approved uses, prescription status, brand-vs-generic options, price, and FDA recall-safety record — which our independent rating scores. The highest-rated is fingolimod hydrochloride.

Top-rated sphingosine 1-phosphate receptor modulator: 1. Fingolimod Hydrochloride · 2. Gilenya · 3. Velsipity

Sphingosine 1-phosphate Receptor Modulator drugs compared side by side, with pharmaranks' FDA recall-safety rating
Drug	Generic	Form	Status	Used for	Safety ratingFDA recall-based	Pharmacy pays
Fingolimod Hydrochloride	—	Capsule	Prescription	Multiple Sclerosis, Relapsing-Remitting	72/100	$144
Gilenya	Fingolimod Hydrochloride	Capsule	Prescription	Multiple Sclerosis, Relapsing-Remitting	70/100	$144
Velsipity	Etrasimod Arginine	Tablet	Prescription	Colitis, Ulcerative	64/100	—
Ponvory	Ponesimod	Tablet	Prescription	Multiple Sclerosis, Relapsing-Remitting	Not yet rated	—
Zeposia	Ozanimod Hydrochloride	Capsule	Prescription	Multiple Sclerosis, Relapsing-Remitting	Not yet rated	—

The safety rating column is unique to pharmaranks — an independent 0–100 score from FDA regulatory recall data. Higher is safer. Not medical advice.

Best sphingosine 1-phosphate receptor modulator by condition

for relapsing-remitting multiple sclerosis

Full ranking · 5 drugs

Frequently asked questions

What is the Sphingosine 1-phosphate Receptor Modulator drug class?

Sphingosine 1-phosphate Receptor Modulator is an FDA Established Pharmacologic Class (EPC) — a group of drugs that share a mechanism of action. pharmaranks lists 5 Sphingosine 1-phosphate Receptor Modulator products, each independently rated.

Are all Sphingosine 1-phosphate Receptor Modulator drugs the same?

No. Sphingosine 1-phosphate Receptor Modulator drugs share the same core mechanism — that is why they sit in one FDA class — but they differ in their approved uses, available forms, whether they are prescription or over-the-counter, brand-vs-generic options and price, and their FDA recall-safety record.

What conditions do Sphingosine 1-phosphate Receptor Modulator drugs treat?

Per NIH RxClass drug-classification data, Sphingosine 1-phosphate Receptor Modulator drugs are used for conditions including multiple sclerosis, relapsing-remitting, colitis, ulcerative.

Which Sphingosine 1-phosphate Receptor Modulator drug is best-rated?

By our independent rating, fingolimod hydrochloride currently ranks highest among Sphingosine 1-phosphate Receptor Modulator drugs. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.

Sources: the Sphingosine 1-phosphate Receptor Modulator class definition and its member drugs come from the U.S. NLM RxClass (Established Pharmacologic Class); how the class works is summarized from Fingolimod - StatPearls - NCBI Bookshelf. Ratings are pharmaranks’ independent FDA recall-safety analysis.