Best treatments for systemic mastocytosis
3 products may treat systemic mastocytosis, spanning FDA drug classes such as kinase inhibitor. The current highest-rated option is gleevec. Ranked below by our independent recall-safety rating (rated where FDA data exists) — not medical advice; always consult a professional.
Quick answer: Of the 3 drugs we list for systemic mastocytosis, 2 are available as lower-cost generics, spanning classes such as kinase inhibitor. They’re ranked by each drug’s FDA recall-safety record — not clinical effectiveness for systemic mastocytosis — so confirm the right choice with your prescriber.
Top-rated picks for systemic mastocytosis: 1. Gleevec · 2. Rydapt · 3. Imkeldi
| # | Drug | Rating | Type | Form | Class | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|---|
| 1 | 70/100 | Prescription | Tablet | Kinase Inhibitor | Generic | $26 | View → | |
| 2 | 70/100 | Prescription | Capsule | — | No data | — | View → | |
| 3 | Not yet rated | Prescription | Solution | Kinase Inhibitor | Generic | $26 | View → |
Narrow by drug class
Explore the class hubs: kinase inhibitor
Full ranking · 3 treatments
gleevec
PrescriptionFDA-sourced
Gleevec (Imatinib Mesylate) is a kinase inhibitor used to treat Lymphoid Leukemia, Myeloid Leukemia, Hypereosinophilic Syndrome, Dermatofibrosarcoma.
Pharmacy pays
From ~$23.82/30· 2 formsrydapt
PrescriptionFDA-sourced
Rydapt (Midostaurin) is a medication used to treat Acute Myeloid Leukemia, Hematologic Neoplasms, Systemic Mastocytosis.
Price varies
imkeldi
PrescriptionFDA-sourced
Imkeldi (Imatinib Mesylate) is a kinase inhibitor used to treat Lymphoid Leukemia, Myeloid Leukemia, Hypereosinophilic Syndrome, Dermatofibrosarcoma.
Pharmacy pays
From ~$23.82/30· 2 formsFrequently asked
- What treats systemic mastocytosis?
- Our catalog lists 3 products that may treat systemic mastocytosis, based on NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. They're rated where FDA recall-safety data exists; the current top-rated option is gleevec.
- What is the best-rated treatment for systemic mastocytosis?
- By our independent recall-safety rating — not an efficacy measure — gleevec ranks highest among the products we list for systemic mastocytosis. Always consult a professional.
- How are these treatments ranked?
- By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.
- What types of drugs treat systemic mastocytosis?
- Treatments for systemic mastocytosis span FDA drug classes including kinase inhibitor. Compare every option side by side, ranked by independent rating, above.
Treatment associations are derived from NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. This is general reference, not medical advice — always consult a licensed professional.