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Best treatments for hiv infections

15 products may treat hiv infections, spanning FDA drug classes such as human immunodeficiency virus 1 non-nucleoside analog reverse transcriptase inhibitor, human immunodeficiency virus integrase strand transfer inhibitor, protease inhibitor. The current highest-rated option is emtriva. Ranked below by our independent recall-safety rating (rated where FDA data exists) — not medical advice; always consult a professional.

Quick answer: Of the 15 drugs we list for hiv infections, 5 are available as lower-cost generics, spanning classes such as human immunodeficiency virus 1 non-nucleoside analog reverse transcriptase inhibitor, human immunodeficiency virus integrase strand transfer inhibitor, protease inhibitor. They’re ranked by each drug’s FDA recall-safety record — not clinical effectiveness for hiv infections — so confirm the right choice with your prescriber.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Understanding hiv infections

HIV (human immunodeficiency virus) harms the immune system by destroying a type of white blood cell that helps the body fight infection, according to MedlinePlus. As these cells are damaged, the body becomes more vulnerable to other infections and diseases. The first signs of infection may be flu-like symptoms — such as fever, chills, rash, night sweats, muscle aches, sore throat, fatigue, swollen lymph nodes, and mouth ulcers — which may come and go within two to four weeks. If the infection is not treated, it becomes chronic HIV infection, and often there are no symptoms during this stage. AIDS (acquired immunodeficiency syndrome) is the final stage of infection with HIV, occurring when the immune system is badly damaged. MedlinePlus notes that a blood test can tell if you have HIV infection. There is no cure for HIV infection, but it can be treated with medicines called antiretroviral therapy (ART). The World Health Organization notes that HIV infection has become a manageable chronic health condition, enabling people living with HIV to lead long and healthy lives. This is general information, not medical advice.

First-line treatment

The standard approach to HIV treatment is antiretroviral therapy (ART). The CDC states that all people with HIV should take HIV treatment, no matter how long they have had HIV or how healthy they are. ART uses medicines, taken as prescribed by a health care provider, to lower the amount of virus in the body (viral load). The World Health Organization recommends the integrase inhibitor dolutegravir (DTG) as the preferred first-line and second-line treatment for all populations, describing it as a drug that is "more effective, easier to take and has fewer side effects than alternative drugs" and noting it "has a high genetic barrier to developing drug resistance." When taken as prescribed, the CDC says HIV medicine can make the viral load so low that a test cannot detect it, and that most people can get HIV under control within six months. A clinician selects and individualizes the specific regimen. This is general information, not medical advice.

Top-rated picks for hiv infections: 1. Emtriva · 2. Nevirapine · 3. Apretude

Top-rated treatments for hiv infections, ranked by pharmaranks score
#DrugRatingPharmacy pays
170/100$435View →
266/100$5View →
3Not yet ratedView →
4Not yet ratedView →
5Not yet ratedView →
6Not yet rated$291View →
7Not yet ratedView →
8Not yet rated$50View →
9Not yet ratedView →
10Not yet ratedView →

Full ranking · 15 treatments

emtriva

Boxed warning

PrescriptionFDA-sourced

70/100

Emtriva (Emtricitabine) is a medication used to treat Hiv Infections.

(4 data points)
hiv infections

Pharmacy pays

~$435.30 /30

View details →

nevirapine

Boxed warning

PrescriptionFDA-sourced

66/100

Nevirapine is a human immunodeficiency virus 1 non-nucleoside analog reverse transcriptase inhibitor used to treat Acquired Immunodeficiency Syndrome, Hiv Infections.

(37 data points)
human immunodeficiency virus 1 non-nucleoside analog reverse transcriptase inhibitoracquired immunodeficiency syndromehiv infections

Pharmacy pays

From ~$4.42/30· 2 forms
View details →

apretude

Boxed warning

PrescriptionFDA-sourced

New

Apretude (Cabotegravir) is a human immunodeficiency virus integrase strand transfer inhibitor used to treat Hiv Infections.

human immunodeficiency virus integrase strand transfer inhibitorhiv infections

Price varies

View details →

edurant

PrescriptionFDA-sourced

New

Edurant (Rilpivirine Hydrochloride) is a medication used to treat Hiv Infections.

hiv infections

Price varies

View details →

edurant ped

PrescriptionFDA-sourced

New

Edurant Ped (Rilpivirine Hydrochloride) is a medication used to treat Hiv Infections.

hiv infections

Price varies

View details →

intelence

PrescriptionFDA-sourced

New

Intelence (Etravirine) is a human immunodeficiency virus 1 non-nucleoside analog reverse transcriptase inhibitor used to treat Hiv Infections.

human immunodeficiency virus 1 non-nucleoside analog reverse transcriptase inhibitorhiv infections

Pharmacy pays

From ~$233.01/30· 2 forms Save up to 98% in class
View details →

Frequently asked

What treats hiv infections?
Our catalog lists 15 products that may treat hiv infections, based on NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. They're rated where FDA recall-safety data exists; the current top-rated option is emtriva.
What is the best-rated treatment for hiv infections?
By our independent recall-safety rating — not an efficacy measure — emtriva ranks highest among the products we list for hiv infections. Always consult a professional.
How are these treatments ranked?
By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.
What types of drugs treat hiv infections?
Treatments for hiv infections span FDA drug classes including human immunodeficiency virus 1 non-nucleoside analog reverse transcriptase inhibitor, human immunodeficiency virus integrase strand transfer inhibitor, protease inhibitor, lymphocyte growth factor, ccr5 co-receptor antagonist. Compare every option side by side, ranked by independent rating, above.

Treatment associations are derived from NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. This is general reference, not medical advice — always consult a licensed professional.

Sources

The clinical overview above is written from these authoritative public-health and medical-society sources, independently reviewed against each.