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Best treatments for herpes genitalis

5 products may treat herpes genitalis, spanning FDA drug classes such as herpes simplex virus nucleoside analog dna polymerase inhibitor, herpes zoster virus nucleoside analog dna polymerase inhibitor, herpesvirus nucleoside analog dna polymerase inhibitor. The current highest-rated option is acyclovir sodium. Ranked below by our independent recall-safety rating (rated where FDA data exists) — not medical advice; always consult a professional.

Quick answer: Of the 5 drugs we list for herpes genitalis, 3 are available as lower-cost generics, spanning classes such as herpes simplex virus nucleoside analog dna polymerase inhibitor, herpes zoster virus nucleoside analog dna polymerase inhibitor, herpesvirus nucleoside analog dna polymerase inhibitor. They’re ranked by each drug’s FDA recall-safety record — not clinical effectiveness for herpes genitalis — so confirm the right choice with your prescriber.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

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Top-rated picks for herpes genitalis: 1. Acyclovir Sodium · 2. Valtrex · 3. Foscarnet Sodium

Top-rated treatments for herpes genitalis, ranked by pharmaranks score
#DrugRatingPharmacy pays
170/100$5View →
270/100$7View →
368/100View →
456/100$5View →
5Not yet ratedView →

Full ranking · 5 treatments

#1 of 4 in Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor

acyclovir sodium

PrescriptionFDA-sourced

70/100

Acyclovir Sodium is a herpes simplex virus nucleoside analog dna polymerase inhibitor used to treat Chickenpox, Herpes Genitalis, Herpes Labialis, Herpes Zoster Ophthalmicus.

(8 data points)
herpes simplex virus nucleoside analog dna polymerase inhibitorherpes zoster virus nucleoside analog dna polymerase inhibitorherpesvirus nucleoside analog dna polymerase inhibitor

Pharmacy pays

From ~$2.22/30· 6 forms
View details →
#1 of 4 in Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor

valtrex

PrescriptionFDA-sourced

70/100

Valtrex (Valacyclovir Hydrochloride) is a herpes simplex virus nucleoside analog dna polymerase inhibitor used to treat Chickenpox, Herpes Genitalis, Herpes Labialis, Herpes Zoster.

(9 data points)
herpes simplex virus nucleoside analog dna polymerase inhibitorherpes zoster virus nucleoside analog dna polymerase inhibitorherpesvirus nucleoside analog dna polymerase inhibitor

Pharmacy pays

From ~$6.87/30· 2 forms Save up to 31% in class
View details →

foscarnet sodium

Boxed warning

PrescriptionFDA-sourced

68/100

Foscarnet Sodium is a pyrophosphate analog dna polymerase inhibitor used to treat Cytomegalovirus Infections, Herpes Genitalis.

(33 data points)
pyrophosphate analog dna polymerase inhibitorcytomegalovirus infectionsherpes genitalis

Price varies

View details →

acyclovir

PrescriptionFDA-sourced

56/100

Acyclovir is a herpes simplex virus nucleoside analog dna polymerase inhibitor used to treat Chickenpox, Herpes Genitalis, Herpes Labialis, Herpes Zoster Ophthalmicus.

(124 data points)
herpes simplex virus nucleoside analog dna polymerase inhibitorherpes zoster virus nucleoside analog dna polymerase inhibitorherpesvirus nucleoside analog dna polymerase inhibitor

Pharmacy pays

From ~$2.22/30· 6 forms
View details →

foscavir

Boxed warning

PrescriptionFDA-sourced

New

Foscavir (Foscarnet Sodium) is a pyrophosphate analog dna polymerase inhibitor used to treat Cytomegalovirus Infections, Herpes Genitalis.

pyrophosphate analog dna polymerase inhibitorcytomegalovirus infectionsherpes genitalis

Price varies

View details →

Frequently asked

What treats herpes genitalis?
Our catalog lists 5 products that may treat herpes genitalis, based on NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. They're rated where FDA recall-safety data exists; the current top-rated option is acyclovir sodium.
What is the best-rated treatment for herpes genitalis?
By our independent recall-safety rating — not an efficacy measure — acyclovir sodium ranks highest among the products we list for herpes genitalis. Always consult a professional.
How are these treatments ranked?
By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.
What types of drugs treat herpes genitalis?
Treatments for herpes genitalis span FDA drug classes including herpes simplex virus nucleoside analog dna polymerase inhibitor, herpes zoster virus nucleoside analog dna polymerase inhibitor, herpesvirus nucleoside analog dna polymerase inhibitor, pyrophosphate analog dna polymerase inhibitor. Compare every option side by side, ranked by independent rating, above.

Treatment associations are derived from NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. This is general reference, not medical advice — always consult a licensed professional.