Best treatments for diabetic neuropathies
6 products may treat diabetic neuropathies, spanning FDA drug classes such as antiarrhythmic, serotonin reuptake inhibitor, serotonin and norepinephrine reuptake inhibitor. The current highest-rated option is mexiletine hydrochloride. Ranked below by our independent recall-safety rating (rated where FDA data exists) — not medical advice; always consult a professional.
Quick answer: Of the 6 drugs we list for diabetic neuropathies, 4 are available as lower-cost generics, spanning classes such as antiarrhythmic, serotonin reuptake inhibitor, serotonin and norepinephrine reuptake inhibitor. 2 of 6 carry a safety score, from 66 to 70 out of 100. They’re ranked by each drug’s FDA recall-safety record — not clinical effectiveness for diabetic neuropathies — so confirm the right choice with your prescriber.
Top-rated picks for diabetic neuropathies: 1. Mexiletine Hydrochloride · 2. Citalopram Hydrobromide · 3. Cymbalta
| # | Drug | Rating | Type | Form | Class | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|---|
| 1 | 70/100 | Prescription | Capsule | Antiarrhythmic | Generic | $8 | View → | |
| 2 | 66/100 | Prescription | Tablet | Serotonin Reuptake Inhibitor | No data | — | View → | |
| 3 | Not yet rated | Prescription | Capsule | Serotonin and Norepinephrine Reuptake Inhibitor | Generic | $3 | View → | |
| 4 | Not yet rated | Prescription | Capsule | Serotonin and Norepinephrine Reuptake Inhibitor | Generic | $3 | View → | |
| 5 | Not yet rated | Prescription | Kit | — | Generic | $0 | View → | |
| 6 | Not yet rated | Prescription | Topical | — | No data | — | View → |
Narrow by drug class
Explore the class hubs: serotonin and norepinephrine reuptake inhibitor
Full ranking · 6 treatments
mexiletine hydrochloride
PrescriptionFDA-sourced
Mexiletine Hydrochloride is an antiarrhythmic used to treat Diabetic Neuropathies, Ventricular Fibrillation, Ventricular Premature Complexes.
Pharmacy pays
From ~$7.23/30· 3 forms Save up to 63% in classcitalopram hydrobromide
Boxed warningPrescriptionFDA-sourced
Citalopram Hydrobromide is a serotonin reuptake inhibitor used to treat Alcoholism, Dementia, Depressive Disorder, Diabetic Neuropathies.
cymbalta
PrescriptionFDA-sourced
Cymbalta (Duloxetine Hydrochloride) is a serotonin and norepinephrine reuptake inhibitor used to treat Anxiety Disorders, Major Depressive Disorder, Diabetic Neuropathies, Musculoskeletal Pain.
Pharmacy pays
From ~$2.86/30· 4 formsdrizalma sprinkle
Boxed warningPrescriptionFDA-sourced
Drizalma Sprinkle (Duloxetine Hydrochloride) is a serotonin and norepinephrine reuptake inhibitor used to treat Anxiety Disorders, Major Depressive Disorder, Diabetic Neuropathies, Musculoskeletal Pain.
Pharmacy pays
From ~$2.86/30· 4 formsqutenza
PrescriptionFDA-sourced
Qutenza (Capsaicin) is a medication used to treat Diabetic Neuropathies, Herpes Zoster, Neuralgia.
Pharmacy pays
From ~$0.07· 4 forms
regranex
PrescriptionFDA-sourced
Regranex (Becaplermin) is a medication used to treat Diabetic Neuropathies.
Price varies
Frequently asked
- What treats diabetic neuropathies?
- Our catalog lists 6 products that may treat diabetic neuropathies, based on NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. They're rated where FDA recall-safety data exists; the current top-rated option is mexiletine hydrochloride.
- What is the best-rated treatment for diabetic neuropathies?
- By our independent recall-safety rating — not an efficacy measure — mexiletine hydrochloride ranks highest among the products we list for diabetic neuropathies. Always consult a professional.
- How are these treatments ranked?
- By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.
- What types of drugs treat diabetic neuropathies?
- Treatments for diabetic neuropathies span FDA drug classes including antiarrhythmic, serotonin reuptake inhibitor, serotonin and norepinephrine reuptake inhibitor. Compare every option side by side, ranked by independent rating, above.
Treatment associations are derived from NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. This is general reference, not medical advice — always consult a licensed professional.
Where this ranking comes from
Our score is computed from public FDA data — not from opinion, sponsorship or user votes. How we rate.
- FDA Drug Enforcement (recall) database — the recall history behind the safety score
- DailyMed (NIH National Library of Medicine) — the FDA labels we quote for uses, dosing and warnings
- Drugs@FDA — approvals, strengths and marketing status