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OMEPRAZOLE AND SODIUM BICARBONATE vs ZEGERID

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Rating

New
New

Pharmacy pays

~$1.52 /30
~$1.52 /30

Type

OTC
RX

Active ingredient

OMEPRAZOLE AND SODIUM BICARBONATE
OMEPRAZOLE AND SODIUM BICARBONATE

Manufacturer

Dosage forms

Capsule
Capsule, Powder

Drug class

Boxed warning

None
None

Half-life

about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults
about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults

Get omeprazole and sodium bicarbonatehigher-rated option

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Where to buy

Buy over-the-counter from trusted retailers.

Frequently asked questions

Which is cheaper, Omeprazole and Sodium Bicarbonate or Zegerid?

Pharmacies pay about the same to acquire either one — roughly $1.52 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Omeprazole and Sodium Bicarbonate and Zegerid?

Both Omeprazole and Sodium Bicarbonate and Zegerid share the active ingredient Omeprazole and Sodium Bicarbonate, but Omeprazole and Sodium Bicarbonate is sold as OTC and Zegerid as RX.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.