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XYLOCAINE vs XYLOCAINE 4% PRESERVATIVE FREE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate
xylocainexylocaine 4% preservative free

Rating

70/100
68/100

Pharmacy pays

$0.24 /mL
$0.24 /mL

Type

RX
RX

Active ingredient

LIDOCAINE HYDROCHLORIDE
LIDOCAINE HYDROCHLORIDE

Manufacturer

Epic Pharma LLC
Fresenius Kabi USA

Dosage forms

Injectable
Injectable, Solution

Drug class

Amide Local Anesthetic
Amide Local Anesthetic

Boxed warning

None
None

Treats

Burns, Esophageal Diseases, Mouth Diseases
Burns, Esophageal Diseases, Mouth Diseases

Frequently asked questions

Which is better-rated, Xylocaine or Xylocaine 4% Preservative Free?

By our independent rating, Xylocaine scores higher — 3.5 vs 3.4 out of 5 for Xylocaine 4% Preservative Free. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Xylocaine or Xylocaine 4% Preservative Free?

Pharmacies pay about the same to acquire either one — roughly $0.24 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Xylocaine and Xylocaine 4% Preservative Free?

Both Xylocaine and Xylocaine 4% Preservative Free share the active ingredient Lidocaine Hydrochloride.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.