TOFRANIL vs TOFRANIL-PM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. TOFRANIL and TOFRANIL-PM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	TOFRANIL	TOFRANIL-PM
Rating	70/100	70/100
Pharmacy pays	~$2.54 /30	~$100.18 /30
Type	RX	RX
Active ingredient	IMIPRAMINE HYDROCHLORIDE	IMIPRAMINE PAMOATE
Manufacturer	Novartis	Specgx LLC
Dosage forms	Tablet, Injectable	Capsule
Drug class	Tricyclic Antidepressant	Tricyclic Antidepressant
Boxed warning	None	None
Treats	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Enuresis	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Enuresis

tofranil tofranil-pm

Rating

70/100

Pharmacy pays

~$2.54 /30

~$100.18 /30

Type

Active ingredient

IMIPRAMINE HYDROCHLORIDE

IMIPRAMINE PAMOATE

Manufacturer

Novartis

Specgx LLC

Dosage forms

Tablet, Injectable

Capsule

Drug class

Tricyclic Antidepressant

Boxed warning

None

Treats

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Enuresis

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Frequently asked questions

Which is better-rated, Tofranil or Tofranil-Pm?

Tofranil and Tofranil-Pm are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Tofranil or Tofranil-Pm?

Tofranil costs pharmacies less to acquire — about $2.54 vs $100.18 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Tofranil and Tofranil-Pm?

Tofranil contains Imipramine Hydrochloride, while Tofranil-Pm contains Imipramine Pamoate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.