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SUBSYS vs WESTADONE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. SUBSYS and WESTADONE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
68/100

Pharmacy pays

$9.51 /mL
$0.18 /mL

Type

RX
RX

Active ingredient

FENTANYL
METHADONE HYDROCHLORIDE

Manufacturer

Dosage forms

Spray/Inhaler
Tablet, effervescent

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

None
None

Half-life

about 8 to 59 hours (terminal/elimination half-life; a very wide range)

Treats

Pain
Opioid-Related Disorders, Intractable Pain

Frequently asked questions

Which is cheaper, Subsys or Westadone?

Westadone costs pharmacies less to acquire — about $0.18 vs $9.51 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Subsys and Westadone?

Subsys contains Fentanyl, while Westadone contains Methadone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.