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SPECTAZOLE vs XOLEGEL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. SPECTAZOLE and XOLEGEL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

70/100
New

Pharmacy pays

$0.36 /g
$0.26 /g

Type

RX
RX

Active ingredient

ECONAZOLE NITRATE
KETOCONAZOLE

Manufacturer

Dosage forms

Topical
Topical

Drug class

Azole Antifungal
Azole Antifungal

Boxed warning

None
None

Treats

Cutaneous Candidiasis, Tinea Pedis, Tinea Versicolor
Blastomycosis, Chronic Mucocutaneous Candidiasis, Cutaneous Candidiasis

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Frequently asked questions

Which is cheaper, Spectazole or Xolegel?

Xolegel costs pharmacies less to acquire — about $0.26 vs $0.36 per gm, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Spectazole and Xolegel?

Spectazole contains Econazole Nitrate, while Xolegel contains Ketoconazole — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.