SARAFEM vs TRAZODONE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. SARAFEM and TRAZODONE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	SARAFEM	TRAZODONE HYDROCHLORIDE
Rating	New	New
Pharmacy pays	$0.05 /mL	~$1.52 /30
Type	RX	RX
Active ingredient	FLUOXETINE HYDROCHLORIDE	TRAZODONE HYDROCHLORIDE
Manufacturer	Eli Lilly and Co	Crossmedika Sa
Dosage forms	Capsule	Tablet
Drug class	Serotonin Reuptake Inhibitor	Serotonin Reuptake Inhibitor
Boxed warning	Boxed warning	None
Half-life	about 1 to 3 days (roughly 24-72 hours) after a single dose, lengthening to about 4 to 6 days with ongoing daily use	about 7 hours (roughly 5 to 9 hours for the slower elimination phase)
Treats	Bulimia, Major Depressive Disorder, Obsessive-Compulsive Disorder	Depressive Disorder, Sleep Initiation and Maintenance Disorders

sarafem trazodone hydrochloride

Rating

New

Pharmacy pays

$0.05 /mL

~$1.52 /30

Type

Active ingredient

FLUOXETINE HYDROCHLORIDE

TRAZODONE HYDROCHLORIDE

Manufacturer

Eli Lilly and Co

Crossmedika Sa

Dosage forms

Capsule

Tablet

Drug class

Serotonin Reuptake Inhibitor

Boxed warning

None

Half-life

about 1 to 3 days (roughly 24-72 hours) after a single dose, lengthening to about 4 to 6 days with ongoing daily use

about 7 hours (roughly 5 to 9 hours for the slower elimination phase)

Treats

Bulimia, Major Depressive Disorder, Obsessive-Compulsive Disorder

Depressive Disorder, Sleep Initiation and Maintenance Disorders

Get trazodone hydrochloride

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Frequently asked questions

What is the difference between Sarafem and Trazodone Hydrochloride?

Sarafem contains Fluoxetine Hydrochloride, while Trazodone Hydrochloride contains Trazodone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.