SAPHRIS vs UZEDY

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Possible drug interaction. SAPHRIS and UZEDY are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	SAPHRIS	UZEDY
Rating	70/100	56/100
Pharmacy pays	~$73.98 /30	~$2.07 /30
Type	RX	RX
Active ingredient	ASENAPINE MALEATE	RISPERIDONE
Manufacturer	Abbvie	Teva
Dosage forms	Tablet	Injectable
Drug class	Atypical Antipsychotic	Atypical Antipsychotic
Boxed warning	Boxed warning	Boxed warning
Half-life	about 24 hours (terminal/elimination half-life)	about 3 hours in extensive CYP2D6 metabolizers (about 20 hours in poor metabolizers)
Treats	Bipolar Disorder, Schizophrenia	Autistic Disorder, Bipolar Disorder, Dementia

saphris uzedy

Rating

70/100

56/100

Pharmacy pays

~$73.98 /30

~$2.07 /30

Type

Active ingredient

ASENAPINE MALEATE

RISPERIDONE

Manufacturer

Abbvie

Teva

Dosage forms

Tablet

Injectable

Drug class

Atypical Antipsychotic

Boxed warning

Half-life

about 24 hours (terminal/elimination half-life)

about 3 hours in extensive CYP2D6 metabolizers (about 20 hours in poor metabolizers)

Treats

Bipolar Disorder, Schizophrenia

Autistic Disorder, Bipolar Disorder, Dementia

Frequently asked questions

Which is better-rated, Saphris or Uzedy?

By our independent rating, Saphris scores higher — 3.5 vs 2.8 out of 5 for Uzedy. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Saphris or Uzedy?

Uzedy costs pharmacies less to acquire — about $2.07 vs $73.98 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Saphris and Uzedy?

Saphris contains Asenapine Maleate, while Uzedy contains Risperidone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.