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SAPHRIS vs SEROQUEL XR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. SAPHRIS and SEROQUEL XR are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

saphrisseroquel xr

Rating

70/100
New

Pharmacy pays

~$73.98 /30
~$2.62 /30

Type

RX
RX

Active ingredient

ASENAPINE MALEATE
QUETIAPINE FUMARATE

Manufacturer

Abbvie
Cheplapharm Arzneimittel Gmbh

Dosage forms

Tablet
Tablet, extended release

Drug class

Atypical Antipsychotic
Atypical Antipsychotic

Boxed warning

Boxed warning
None

Half-life

about 24 hours (terminal/elimination half-life)
about 6 hours

Treats

Bipolar Disorder, Schizophrenia
Autistic Disorder, Bipolar Disorder, Major Depressive Disorder

Frequently asked questions

Which is cheaper, Saphris or Seroquel XR?

Seroquel XR costs pharmacies less to acquire — about $2.62 vs $73.98 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Saphris and Seroquel XR?

Saphris contains Asenapine Maleate, while Seroquel XR contains Quetiapine Fumarate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.