RYTHMOL vs SORINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. RYTHMOL and SORINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	RYTHMOL	SORINE
Rating	70/100	New
Pharmacy pays	~$10.51 /30	~$2.96 /30
Type	RX	RX
Active ingredient	PROPAFENONE HYDROCHLORIDE	SOTALOL HYDROCHLORIDE
Manufacturer	Glaxosmithkline	Aiping Pharm Inc
Dosage forms	Tablet	Tablet
Drug class	Antiarrhythmic	Antiarrhythmic
Boxed warning	None	Boxed warning
Half-life	about 2 to 10 hours (immediate-release) in the ~90% of adults who are extensive CYP2D6 metabolizers	about 12 hours (the label gives a mean elimination half-life of 12 hours)
Treats	Atrial Fibrillation, Supraventricular Tachycardia	Atrial Fibrillation, Atrial Flutter, Supraventricular Tachycardia

rythmol sorine

Rating

70/100

New

Pharmacy pays

~$10.51 /30

~$2.96 /30

Type

Active ingredient

PROPAFENONE HYDROCHLORIDE

SOTALOL HYDROCHLORIDE

Manufacturer

Glaxosmithkline

Aiping Pharm Inc

Dosage forms

Tablet

Drug class

Antiarrhythmic

Boxed warning

None

Boxed warning

Half-life

about 2 to 10 hours (immediate-release) in the ~90% of adults who are extensive CYP2D6 metabolizers

about 12 hours (the label gives a mean elimination half-life of 12 hours)

Treats

Atrial Fibrillation, Supraventricular Tachycardia

Atrial Fibrillation, Atrial Flutter, Supraventricular Tachycardia

Frequently asked questions

Which is cheaper, Rythmol or Sorine?

Sorine costs pharmacies less to acquire — about $2.96 vs $10.51 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Rythmol and Sorine?

Rythmol contains Propafenone Hydrochloride, while Sorine contains Sotalol Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.