REXULTI vs SAPHRIS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. REXULTI and SAPHRIS are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	REXULTI	SAPHRIS
Rating	New	70/100
Pharmacy pays	—	~$73.98 /30
Type	RX	RX
Active ingredient	BREXPIPRAZOLE	ASENAPINE MALEATE
Manufacturer	Otsuka	Abbvie
Dosage forms	Tablet, Kit	Tablet
Drug class	Atypical Antipsychotic	Atypical Antipsychotic
Boxed warning	Boxed warning	Boxed warning
Half-life	—	about 24 hours (terminal/elimination half-life)
Treats	Major Depressive Disorder, Schizophrenia	Bipolar Disorder, Schizophrenia

rexulti saphris

Rating

New

70/100

Pharmacy pays

—

~$73.98 /30

Type

Active ingredient

BREXPIPRAZOLE

ASENAPINE MALEATE

Manufacturer

Otsuka

Abbvie

Dosage forms

Tablet, Kit

Tablet

Drug class

Atypical Antipsychotic

Boxed warning

Half-life

—

about 24 hours (terminal/elimination half-life)

Treats

Major Depressive Disorder, Schizophrenia

Bipolar Disorder, Schizophrenia

Frequently asked questions

What is the difference between Rexulti and Saphris?

Rexulti contains Brexpiprazole, while Saphris contains Asenapine Maleate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.