PROSTAPHLIN vs UNIPEN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. PROSTAPHLIN and UNIPEN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	PROSTAPHLIN	UNIPEN
Rating	New	New
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	OXACILLIN SODIUM	NAFCILLIN SODIUM
Manufacturer	Apothecon	Wyeth Ayerst
Dosage forms	Capsule	Injectable
Drug class	Penicillin-Class Antibacterial	Penicillin-Class Antibacterial
Boxed warning	None	None
Treats	Cellulitis, Bacterial Endocarditis, Osteomyelitis	Cellulitis, Bacterial Endocarditis, Osteomyelitis

prostaphlin unipen

Rating

New

Pharmacy pays

—

Type

Active ingredient

OXACILLIN SODIUM

NAFCILLIN SODIUM

Manufacturer

Apothecon

Wyeth Ayerst

Dosage forms

Capsule

Injectable

Drug class

Penicillin-Class Antibacterial

Boxed warning

None

Treats

Cellulitis, Bacterial Endocarditis, Osteomyelitis

Frequently asked questions

What is the difference between Prostaphlin and Unipen?

Prostaphlin contains Oxacillin Sodium, while Unipen contains Nafcillin Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.