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unipen

Unipen (Nafcillin Sodium) is a penicillin-class antibacterial used to treat Cellulitis, Bacterial Endocarditis, Osteomyelitis, Postoperative Complications.

Nafcillin Sodium · by Wyeth Ayerst

Available as a generic: Nafcillin Sodium

Not yet rated· sourced from the FDA label
Rated against independent regulatory sources·Last updated June 7, 2026·How we rate
Verified againstopenFDANIH DailyMedRxClass

Key facts

Active ingredient
Nafcillin Sodium
Form
Injectable
Strength
Nafcillin Sodium EQ 250MG Base
Type
Prescription (Rx)
Brand or generic
Brand-name
Manufacturer
Wyeth Ayerst
FDA application
NDA050111
Availability
Discontinued (per FDA)

Drug class

May treat (source: NIH RxClass)

Dosage forms

Injectable

The forms currently marketed in the U.S., per the FDA National Drug Code Directory.

Ways to save

Ask for the generic

Same active ingredient, far cheaper. Is there a generic? →

Request a 90-day supply

Bulk fills usually lower the per-dose price vs monthly refills.

Use copay cards

Manufacturer copay cards & patient-assistance programs — especially for brand drugs.

Compare alternatives

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Frequently asked questions

What does Unipen treat?
Unipen (Nafcillin Sodium) may be used to treat cellulitis, bacterial endocarditis, osteomyelitis, postoperative complications, respiratory tract infections, staphylococcal infections, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
Is there a coupon or discount for Unipen?
pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Unipen. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
Who makes Unipen?
Unipen is marketed by Wyeth Ayerst. You can see Wyeth Ayerst's full profile, rating, and other products on pharmaranks.
Is Unipen a brand-name or generic drug?
Unipen is a brand-name product with the active ingredient Nafcillin Sodium. Lower-cost generic equivalents containing Nafcillin Sodium are available — ask your pharmacist.
Is Unipen available over the counter?
No. Unipen is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
What forms does Unipen come in?
Unipen is currently marketed as injectable, per the FDA's National Drug Code Directory.
What class of drug is Unipen?
Unipen is classified as penicillin-class antibacterial, per the FDA's Established Pharmacologic Class.
Is Unipen FDA-registered?
Unipen is on record with the U.S. FDA under application number NDA050111. You can verify this on its official FDA label.

Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.

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