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PROMETHAZINE HYDROCHLORIDE vs STELAZINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. PROMETHAZINE HYDROCHLORIDE and STELAZINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
70/100

Pharmacy pays

~$1.53 /30
~$22.02 /30

Type

RX
RX

Active ingredient

PROMETHAZINE HYDROCHLORIDE
TRIFLUOPERAZINE HYDROCHLORIDE

Dosage forms

Injectable, Solution, Syrup, Tablet
Tablet

Drug class

Phenothiazine
Phenothiazine

Boxed warning

None
None

Half-life

about 9 to 16 hours

Treats

Anaphylaxis, Allergic Conjunctivitis, Motion Sickness
Anxiety Disorders, Psychotic Disorders, Schizophrenia

Frequently asked questions

Which is cheaper, Promethazine Hydrochloride or Stelazine?

Promethazine Hydrochloride costs pharmacies less to acquire — about $1.53 vs $22.02 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Promethazine Hydrochloride and Stelazine?

Promethazine Hydrochloride contains Promethazine Hydrochloride, while Stelazine contains Trifluoperazine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.