PRILOSEC vs PRILOSEC OTC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Attribute	PRILOSEC	PRILOSEC OTC
Rating	70/100	70/100
Pharmacy pays	~$1.52 /30	—
Type	RX	OTC
Active ingredient	OMEPRAZOLE	OMEPRAZOLE MAGNESIUM
Manufacturer	Astrazeneca	Astrazeneca
Dosage forms	Powder, delayed release	Tablet, delayed release
Drug class	Proton Pump Inhibitor	Proton Pump Inhibitor
Boxed warning	None	None
Half-life	about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults	about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults
Treats	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

prilosec prilosec otc

Rating

70/100

Pharmacy pays

~$1.52 /30

—

Type

OTC

Active ingredient

OMEPRAZOLE

OMEPRAZOLE MAGNESIUM

Manufacturer

Astrazeneca

Dosage forms

Powder, delayed release

Tablet, delayed release

Drug class

Proton Pump Inhibitor

Boxed warning

None

Half-life

about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults

Treats

Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

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Frequently asked questions

Which is better-rated, Prilosec or Prilosec OTC?

Prilosec and Prilosec OTC are tied at 3.5 out of 5 by our independent rating.

What is the difference between Prilosec and Prilosec OTC?

Prilosec contains Omeprazole, while Prilosec OTC contains Omeprazole Magnesium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.