PREVACID 24 HR vs PRILOSEC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Attribute	PREVACID 24 HR	PRILOSEC
Rating	64/100	70/100
Pharmacy pays	~$5.10 /30	~$1.52 /30
Type	OTC	RX
Active ingredient	LANSOPRAZOLE	OMEPRAZOLE
Manufacturer	Perrigo	Astrazeneca
Dosage forms	Capsule, delayed release	Powder, delayed release
Drug class	Proton Pump Inhibitor	Proton Pump Inhibitor
Boxed warning	None	None
Half-life	about 1.5 hours (mean, ±1.0) in healthy adults — the label states the plasma elimination half-life is less than two hours	about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults
Treats	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

prevacid 24 hr prilosec

Rating

64/100

70/100

Pharmacy pays

~$5.10 /30

~$1.52 /30

Type

OTC

Active ingredient

LANSOPRAZOLE

OMEPRAZOLE

Manufacturer

Perrigo

Astrazeneca

Dosage forms

Capsule, delayed release

Powder, delayed release

Drug class

Proton Pump Inhibitor

Boxed warning

None

Half-life

about 1.5 hours (mean, ±1.0) in healthy adults — the label states the plasma elimination half-life is less than two hours

about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults

Treats

Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

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Frequently asked questions

Which is better-rated, Prevacid 24 Hr or Prilosec?

By our independent rating, Prilosec scores higher — 3.5 vs 3.2 out of 5 for Prevacid 24 Hr. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Prevacid 24 Hr or Prilosec?

Prilosec costs pharmacies less to acquire — about $1.52 vs $5.10 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Prevacid 24 Hr and Prilosec?

Prevacid 24 Hr contains Lansoprazole, while Prilosec contains Omeprazole — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.